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\begin{document}

\title{Advancements in SERS-Based Biological Detection and Its Application and
Perspectives in Pancreatic Cancer}



\author[1]{Lei Xu}%
\author[2]{Yujiao Xie}%
\author[3]{Jie Lin}%
\author[3]{Aiguo Wu}%
\author[1]{Tianan Jiang}%
\affil[1]{Zhejiang University School of Medicine}%
\affil[2]{Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences}%
\affil[3]{Ningbo Institute of Materials Technology and Engineering CAS}%


\vspace{-1em}



  
  \date{June 08, 2024}


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\begin{abstract}
Surface-enhanced Raman scattering (SERS) has become an essential
bio-detection technique. Due to its high sensitivity, good signal
specificity, and resistance to photobleaching, SERS has been widely used
in biomedical research fields such as molecular imaging, tumor
diagnosis, and drug monitoring. This review focuses on the progress of
SERS in biomedical applications. We first introduce the basic principle
of SERS and the progress of substrate research. Then we summarize the
latest research progress of SERS in drug monitoring, cell and exosome
detection, tumor imaging, and detection platforms combining microfluidic
and lateral flow technologies. Subsequently, the applied research of
SERS in early diagnosis of pancreatic cancer and drug efficacy
monitoring is described. Finally, the future development direction and
possible challenges of SERS in tumor diagnosis and treatment are
proposed.%
\end{abstract}%



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