Abstract
Objective: This case report describes the second reported case
of ectopic production of beta-hCG in anal cancer
Case: 53-year-old female presented with a new anal lesion.
Biopsy showed a poorly differentiated squamous cell cancer (SCC) with
undifferentiated sarcomatoid features, stage IIIA (cT2cN1cM0). Before
starting concurrent chemotherapy and radiation, the patient had a
positive urine pregnancy test. The beta-human chorionic gonadotropin
(beta-hCG) production was attributed to the tumor, and upon completion
of treatment, beta-hcg normalized. Six weeks from treatment completion,
recurrence was noted along with (+) beta-hCG urine testing.
Conclusion: This case aims to highlight beta-hCG as an ectopic
hormone that can indicate the presence of squamous cell anal cancer and
discuss the potential implication it may have on management.
Keywords: Anal Cancer, Ectopic Hormones, Multidisciplinary Care,
Diagnostic Techniques