1 Introduction
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disorder
caused by tumors that secrete fibroblast growth factor 23
(FGF23).1 Because of its role in renal phosphate
handling and vitamin D synthesis, TIO is associated with decreased renal
phosphate tubular reabsorption, hypophosphatemia, and low active vitamin
D levels. Patients are often affected by the muscular vulnerability and
bone pain for a prolonged time before diagnosis due to
osteomalacia.2,3
The majority of tumors that cause TIO are classified as phosphaturic
mesenchymal tumors (PMTs).4 Head and neck regions were
the second most constant localization of tumor (26%), next to the lower
limbs (46%).2 Previous research on PMT in the head
and neck region was primarily case reports with short-term
follow-ups.5-7 Although comprehending the long-term
surgical result and the cases with residual/local recurrent tumors is
crucial for clinical administration, only a few reports have focused on
nonremission and recurrent PMT cases.8 There remains a
paucity of studies on long-term surgical and biochemical outcomes of PMT
in the head and neck area.
Therefore, the purpose of this study was to determine the long-term
surgical and biochemical outcomes of PMT in the head and neck region,
particularly in nonremission and recurrent cases. These outcomes were
also compared with PMT in the extremities and trunk.