Key points:
There have been a few reports on the surgical outcomes of phosphaturic mesenchymal tumors causing tumor-induced osteomalacia in the head and neck.
・Tumor-induced osteomalacia is a rare and underreported condition because treating clinicians are unaware of its clinical characteristics. We highlighted our experience with Tumor-induced osteomalacia cases in the head and neck regions.
・Phosphaturic mesenchymal tumor resection in the head and neck region was associated with high local recurrence/residual disease rate.
・Before definitive resection, surgeons should discuss with their patients the difficulty of obtaining clear margins due to the complex anatomy.
・Re-excision lead to biological remission in the majority of the patients after re-excision.