Multivariable Analysis of Associations between LA Reservoir, Contractile, and Conduit Strain and ESUS
On binary logistic regression analysis utilizing LA strain as tertiles, the lowest tertiles (Tertile 1) of LA reservoir (OR 1.860, 95% CI 1.272-2.721, p = 0.001), contractile (OR 1.845, 95% CI 1.261-2.699, p = 0.002), and conduit (OR 1.930, 95% CI 1.319-2.825, p = 0.001) strain were associated with ESUS compared to NCE (Table 2). After adjustment, low LA reservoir (OR 1.944, 95% CI 1.266-2.986, p = 0.002), contractile (OR 1.568, 95% CI 1.035-2.374, p = 0.034), and conduit (OR 2.288, 95% CI 1.448-3.613, p = 0.001) strain continued to be significantly associated with ESUS compared to NCE.
On binary logistic regression analyses utilizing LA strain as continuous variables, there was an inverse relationship of higher LA reservoir (OR 0.983, 95% CI 0.974-0.993, p = 0.001) and conduit (OR 0.977, 95% CI 0.962-0.991, p = 0.001) strain and ESUS compared to NCE in the unadjusted model, and these findings persisted after adjustment (reservoir strain OR 0.985, 95% CI 0.974-0.995, p = 0.005; conduit strain OR 0.971, 95% CI 0.955-0.988, p = 0.001) (Table 2). There was also an inverse association of higher LA contractile strain and ESUS compared to NCE in the unadjusted model (OR 0.982, 95% CI 0.966-0.997, p = 0.019); though the effect size remained the same, the association was no longer significant after adjustment for confounding variables (OR 0.990, 95% CI 0.973-1.007, p = 0.239).