Multivariable Analysis of Associations between LA strain
and Atrial Fibrillation Detection in ESUS patients
Among all ESUS patients, in binary logistic analysis using LA strain as
tertiles, the lowest tertile of strain values (Tertile 1) showed
significant association of LA reservoir strain (unadjusted OR 2.534,
95% CI 1.029-6.236, p = 0.043), LA contractile strain (unadjusted OR
2.828, 95% CI 1.158-6.903, p = 0.022) and LA conduit strain (unadjusted
OR 2.614, 95% CI 1.003-6.815, p = 0.049) with AF detection (Table 5).
When utilizing LA strain as a continuous variable, decreased LA
reservoir strain (unadjusted OR 0.957, 95% CI 0.929-0.987, p = 0.005),
LA contractile strain (unadjusted OR 0.949, 95% CI 0.907-0.993, p =
0.025), and LA conduit strain (unadjusted OR 0.952, 95% CI 0.912-0.994,
p = 0.025) were significantly associated with detection of AF (Table 5).
Findings remain unchanged in the sensitivity analyses adjusting for age.
In the sensitivity analysis using only the 155 ESUS patients who
received cardiac monitoring, the effect size of LA strain remained
stable but significance was lost likely due to small sample size
(Supplementary Table 2).