Multivariable Analysis of Associations between LA
Reservoir, Contractile, and Conduit Strain and ESUS
On binary logistic regression analysis utilizing LA strain as tertiles,
the lowest tertiles (Tertile 1) of LA reservoir (OR 1.860, 95% CI
1.272-2.721, p = 0.001), contractile (OR 1.845, 95% CI 1.261-2.699, p =
0.002), and conduit (OR 1.930, 95% CI 1.319-2.825, p = 0.001) strain
were associated with ESUS compared to NCE (Table 2). After adjustment,
low LA reservoir (OR 1.944, 95% CI 1.266-2.986, p = 0.002), contractile
(OR 1.568, 95% CI 1.035-2.374, p = 0.034), and conduit (OR 2.288, 95%
CI 1.448-3.613, p = 0.001) strain continued to be significantly
associated with ESUS compared to NCE.
On binary logistic regression analyses utilizing LA strain as continuous
variables, there was an inverse relationship of higher LA reservoir (OR
0.983, 95% CI 0.974-0.993, p = 0.001) and conduit (OR 0.977, 95% CI
0.962-0.991, p = 0.001) strain and ESUS compared to NCE in the
unadjusted model, and these findings persisted after adjustment
(reservoir strain OR 0.985, 95% CI 0.974-0.995, p = 0.005; conduit
strain OR 0.971, 95% CI 0.955-0.988, p = 0.001) (Table 2). There was
also an inverse association of higher LA contractile strain and ESUS
compared to NCE in the unadjusted model (OR 0.982, 95% CI 0.966-0.997,
p = 0.019); though the effect size remained the same, the association
was no longer significant after adjustment for confounding variables (OR
0.990, 95% CI 0.973-1.007, p = 0.239).