3.1.3.2 The changes of N-glycan profile were different between
genders.
During aging, the total core-α-1,6-fucose level of males remained
unchanged. In contrast, the incidence in the youngest age group of women
began to be higher, but then gradually decreased with age, reaching a
similar level[56]. The results showed that serum glycans were also
closely related to age and gender[57]. Serum N-glycan levels changed
significantly with age. Polysaccharides with the same variation trend in
both sexes are more useful as age-related markers. The different trends
between men and women suggest that gender should be considered in the
development of serum glycomic markers. N-glycan profiling should be
studied more extensively, such as long-term longitudinal studies. The
serum glycan profile is easy to derive, and it can be developed as an
accurate biomarker that can indicate physiological age[58, 59].
These results may help to establish a specific blood monitoring
technique based on accurate markers of gender and age-related diseases
in men and women.