3.1 Glycomics research reveals emerging targets for disease diagnosis and treatment
Glycomics is mainly a new subject to study the structure and function of the body’s glycans. In recent years, the correlation between glycan changes and various diseases has been increasing. Diabetes is a chronic disease with a high incidence worldwide. Diabetic patients generally have a variety of pathophysiological changes and metabolic disorders, especially glucose metabolism disorders. At present, many studies have reported that diabetes is associated with changes in the sugar group. The number, structure and immunoglobulin G N-glycans in the serum of diabetic patients have changed, and N-glycans may be used as diabetes biomarkers. The number and structure of glycans on glycoproteins are closely related to the body’s blood glucose levels and diabetes progression[27-30]. Therefore, glycomics has potential application value in the diagnosis, prediction and prognosis of diabetes and other diseases. There have been many reports on its related research, mainly focusing on the changes of N-glycans in the occurrence and development of diabetes and its correlation with diabetic kidney disease, cardiovascular disease and other complications[31].