3.1.4 Research progress of IgG N-glycomics in patients with
breast hyperplasia
Mammary gland hyperplasia (MGH) is very common in young and middle-aged
women. Immunoglobulin G (IgG) is a glycosylated molecule that accounts
for about 75% of serum immunoglobulin and plays an important role in
the regulation of inflammatory response. The association between IgG
N-glycosylation and MGH has been reported[60]. The serum levels of
the five initial characteristics and seven derivative characteristics of
glycans between MGH and healthy individuals are different. Although the
sensitivity and specificity of the current predictive association are
not up to the diagnostic level of conventional clinical use, this
finding shows the prospect of glycomics. The difference in IgG N-glycans
between people and their combination with multiple sets of student
biomarker strategies provides a promising way to identify MGH risk
populations and diagnose MGH (Figure 2).