3.1.3.1 Serum N-glycan profile has potential as a biomarker of aging
It has been previously reported that the serum N-glycan profile of Belgians and Italians has changed during aging, and its potential as a biomarker for aging has been proposed[54]. The 12 most significant N-glycan structures were analyzed by exoglycosidase digestion[55]. Finally, it was found that the relative abundance of the three main N-glycan structures (NGA2F, NGA2FB and NA2F) changed significantly with age, and had the same variation trend in both sexes, which made the serum N-glycan profile have the potential as a biomarker of aging.