3.1.3.2 The changes of N-glycan profile were different between genders.
During aging, the total core-α-1,6-fucose level of males remained unchanged. In contrast, the incidence in the youngest age group of women began to be higher, but then gradually decreased with age, reaching a similar level[56]. The results showed that serum glycans were also closely related to age and gender[57]. Serum N-glycan levels changed significantly with age. Polysaccharides with the same variation trend in both sexes are more useful as age-related markers. The different trends between men and women suggest that gender should be considered in the development of serum glycomic markers. N-glycan profiling should be studied more extensively, such as long-term longitudinal studies. The serum glycan profile is easy to derive, and it can be developed as an accurate biomarker that can indicate physiological age[58, 59]. These results may help to establish a specific blood monitoring technique based on accurate markers of gender and age-related diseases in men and women.