3.1.4 Research progress of IgG N-glycomics in patients with breast hyperplasia
Mammary gland hyperplasia (MGH) is very common in young and middle-aged women. Immunoglobulin G (IgG) is a glycosylated molecule that accounts for about 75% of serum immunoglobulin and plays an important role in the regulation of inflammatory response. The association between IgG N-glycosylation and MGH has been reported[60]. The serum levels of the five initial characteristics and seven derivative characteristics of glycans between MGH and healthy individuals are different. Although the sensitivity and specificity of the current predictive association are not up to the diagnostic level of conventional clinical use, this finding shows the prospect of glycomics. The difference in IgG N-glycans between people and their combination with multiple sets of student biomarker strategies provides a promising way to identify MGH risk populations and diagnose MGH (Figure 2).