3.3.1 Application of glycomics research method in TCM disease
state
The normal spatial structure and normal functional status of the sugar
group is one of the important conditions for maintaining the normal life
activities of the human body. The physiological characteristics of the
sugar group are reflected in the normal physiological characteristics of
the human body, which are the microscopic parameters of the disease-free
state in the state of traditional Chinese medicine. When people respond
to the relatively mild stimulation of external factors, they can control
the state in the state of disease or disease-free state without changing
to the state of disease by virtue of their own regulatory mechanism of
”yin and yang harmony”. When the degree of external stimulation
exceeds the scope of the human body’s self-regulation ability, the human
state will enter the disease state.
Under the stimulation of external pathogenic factors, the sugar group in
the human body will undergo corresponding abnormal structure, resulting
in changes in the spatial structure and function of the sugar group,
eventually leading to the occurrence of diseases and changes in the
state of the human body. In the process of disease development, the
change of glycome plays an important role. The change of glycosylation
is often related to the occurrence of disease. Glycomics can provide
microscopic parameters for the state of traditional Chinese medicine.
Modern research shows that[66], in the process of disease
development, especially cancer, due to changes in the activity of
oligosaccharide chain metabolic enzymes, can cause abnormal glycan
structure, which leads to the dysfunction of glycoproteins and their
cells, and even malignant phenotypes, such as malignant tumors.
Therefore, the study of glycomics can enrich the microscopic parameters
of TCM state, provide some reference for the microscopic identification
of state, and provide reference data for the establishment of TCM
microscopic identification database.