3.3.1 Application of glycomics research method in TCM disease state
The normal spatial structure and normal functional status of the sugar group is one of the important conditions for maintaining the normal life activities of the human body. The physiological characteristics of the sugar group are reflected in the normal physiological characteristics of the human body, which are the microscopic parameters of the disease-free state in the state of traditional Chinese medicine. When people respond to the relatively mild stimulation of external factors, they can control the state in the state of disease or disease-free state without changing to the state of disease by virtue of their own regulatory mechanism of ”yin and yang harmony”. When the degree of external stimulation exceeds the scope of the human body’s self-regulation ability, the human state will enter the disease state.
Under the stimulation of external pathogenic factors, the sugar group in the human body will undergo corresponding abnormal structure, resulting in changes in the spatial structure and function of the sugar group, eventually leading to the occurrence of diseases and changes in the state of the human body. In the process of disease development, the change of glycome plays an important role. The change of glycosylation is often related to the occurrence of disease. Glycomics can provide microscopic parameters for the state of traditional Chinese medicine. Modern research shows that[66], in the process of disease development, especially cancer, due to changes in the activity of oligosaccharide chain metabolic enzymes, can cause abnormal glycan structure, which leads to the dysfunction of glycoproteins and their cells, and even malignant phenotypes, such as malignant tumors. Therefore, the study of glycomics can enrich the microscopic parameters of TCM state, provide some reference for the microscopic identification of state, and provide reference data for the establishment of TCM microscopic identification database.