3.1 Glycomics research reveals emerging targets for disease
diagnosis and treatment
Glycomics is mainly a new subject to study the structure and function of
the body’s glycans. In recent years, the correlation between glycan
changes and various diseases has been increasing. Diabetes is a chronic
disease with a high incidence worldwide. Diabetic patients generally
have a variety of pathophysiological changes and metabolic disorders,
especially glucose metabolism disorders. At present, many studies have
reported that diabetes is associated with changes in the sugar group.
The number, structure and immunoglobulin G N-glycans in the serum of
diabetic patients have changed, and N-glycans may be used as diabetes
biomarkers. The number and structure of glycans on glycoproteins are
closely related to the body’s blood glucose levels and diabetes
progression[27-30]. Therefore, glycomics has potential application
value in the diagnosis, prediction and prognosis of diabetes and other
diseases. There have been many reports on its related research, mainly
focusing on the changes of N-glycans in the occurrence and development
of diabetes and its correlation with diabetic kidney disease,
cardiovascular disease and other complications[31].