Han-Qi Mo

and 2 more

Bronchopulmonary dysplasia (BPD) also named chronic lung disease, is one of the most important morbidities affecting preterm babies due to improved survivals of them. The disease also accounts significantly for mortality among premature infants. There are a large number of consequence of the disease, affecting the lung function trajectories that the survivor attains. What is more, BPD also has long-term respiratory complications. Throughout the world, chronic obstructive pulmonary disease (COPD) is characterized as a disease with high morbidity and mortality. The disease has many causative factors including biological and environmental ones. Early life events such as BPD seem to be a predictor of early onset COPD. BPD and COPD have some commonalities in their pathogenesis, pathological features, clinical manifestations, pulmonary functions, and outcomes. Some similarities between the diseases are as follows. The environmental factors include in-utero exposure to maternal smoke, while biological factors include familial aggregation, higher occurrence among twins. Factors are associated with the pathogenesis of both diseases, pathological features and alveolar simplification, large alveoli with reduced compliance, clinical features and respiratory distress and pulmonary function and airflow resistance, reduced FEV1. In BPD survivors, there is attainment of less than maximally expected lung function as measured by FEV1, and these patients tend to develop COPD at much younger ages. Therefore, it is of great significance to further explore the association between BPD and COPD.