Figure 8
Intervention with hydralazine does not reverse angiotensin II-induced immune cell infiltration in the brain and cognitive impairment. A: Angiotensin II-induced hypertension and effect of intervention with hydralazine (n=7-8). All data are mean ± S.E.M. *P<0.05. Two-way ANOVA with Tukey’s test. B:Representative flow cytometry dot plots showing gating strategy for total leukocytes (CD45+ high) from the brains of mice infused with angiotensin II and angiotensin II + hydralazine. C: The effect of intervention with hydralazine on angiotensin II-induced leukocyte infiltration in the brain (n=7-8). All data are mean ± S.E.M.D: Representative heatmaps showing interaction between familiar and novel objects in mice infused with angiotensin II and angiotensin II + hydralazine. E: The effect of intervention with hydralazine on angiotensin II-induced cognitive impairment (n=7-8). All data are mean ± S.E.M.