Results

The goal of the first suite of tests was to determine if AKAP11 has some effect on the diagnosis of SCZ or BPD using the amino acid distributions of its variants.  We use the results from the logistic ordinal regression to quantify the probability that each listed variant is statistically likely to be pathogenic.  The relative probabilities for these AKAP11 variants for both SCZ and BPD are shown in Fig. \ref{378760}, where a larger line indicates a larger probability.  In Fig. \ref{378760}a, the relative probabilities of AKAP11 variants on schizophrenia are shown.  Here, the probabilities of each variant are relatively concentrated with a few minor extremes; however, in Fig. \ref{378760}b which demonstrates the effect on bipolar I diagnoses, the probability variance is much more dramatic and spread out along the chromosome.