These amino acid frequencies of the top 10% of variants with the largest \(\mathbb{P}(j=4)\) are compared against natural amino acid frequencies to test for discrepancies using \(\chi^2\). Table \ref{amino-acid-distribution} shows the recorded amino acid frequencies with their expected frequencies taken from \citet{Moura2013}.  Interestingly, when taking the top 3 amino acids with the highest adjusted differences between observed and expected frequencies for BPD and SCZ, we find that both disorders are most affected by identical amino acids (Leu, Ser, and Val), indicating a strong genetic linkage.