Methods
Having demonstrated the basis for related genetic predispositions to
schizophrenia and bipolar disease, we turn our attention to a novel
methodology of determining the statistical significance of AKAP11 in the pathogenesis of these two diseases. Specifically, we use AKAP11 variants to investigate its link to BPD and SCZ.
Subsequently, frequencies of severe variants are compared against
frequencies of BPD and SCZ across Canada.