3.4 Cox proportional hazards models
Table 2 shows the results of the Cox proportional hazards models examining the risk of all-cause mortality in the PAH patients reported in the JADER database. According to the results of the univariate and the Kaplan-Meier analyses, we selected 12 variables (sex, age, epoprostenol, sildenafil, tadalafil, bosentan, ambrisentan, macitentan, oxygen, warfarin, DOAC, and tolvaptan) for the multivariate analysis (Model 1). The significant variables in Model 1 and the interaction between epoprostenol and warfarin were adjusted in Model 2 as a final model. The HRs of all variables in the univariate analyses were demonstrated in Supplementary Table S2.