Figure 7. Alterations in lung mechanics in mice instilled with S1SP and treated with KVX-053. KVX-053 reversed the S1SP-induced downward shift in pressure-volume loops (PV loops) (A). Respiratory system compliance (Crs) and static compliance (Cst) were reduced in S1SP-treated mice but were at normal levels in mice, receiving KVX-053 (B). Mice instilled with S1SP and treated with KVX-053 showed a decrease in total respiratory system resistance (Rrs), total elastance (Ers), Newtonian resistance (Rn), and tissue damping (G) in response to methacholine compared to mice, instilled with S1SP, and receiving placebo (C). Means ± SEM; n = 6-7 mice per group; * p < 0.05, ** p < 0.01, *** p < 0.001, with one-way ANOVA and Tukey’s test.