Fig.1. Experimental Design. K18-hACE2 transgenic mice were intratracheally instilled with SARS-CoV-2 S1SP or saline and at 1, 24, and 48 h were treated intraperitoneally with PTP4A3 inhibitor KVX-053 or vehicle. 72 h after instillation, lungs, BALF, and blood were collected for analysis.