Palladium-catalyzed denitrogenative self-carbonylation of
arylhydrazine using CO and O2 as an ideal oxidant
Yuvraj A. Kolekar, a and Bhalchandra M. Bhanage
*, aChin. J. Chem.2022, 40, XXX—XXX. DOI:
10.1002/cjoc.202200XXX
Pd/Cu-catalyzed denitrogenative self-carbonylation of arylhydrazine
hydrochlorides to synthesize symmetrical biaryl ketones under
CO/O2 pressure has been developed. The arylhydrazine
hydrochlorides are used as a green arylating agent which releases
nitrogen and water as a byproduct. This developed protocol significantly
restricts the formation of aryl iodide and azobenzene products even
under favorable conditions. Additionally, this protocol provides a
series of symmetric carbonylative ketones with a wide variety of
functional group tolerance under CO/O2 pressure.
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