Figure 1. Lung histopathology analyses of COVID-19 patients.
Autopsy lung samples collected from COVID-19 patients show major
patterns of (A) widespread diffuse alveolar damage, and (B) fibrosing
organizing pneumonia. Fibrotic changes in COVID-19 patients show
variable patterns including (C) interstitial fibrotic development (black
arrows), (D) intra-alveolar fibrin deposition and organizing fibrosis
showing spreading of fibrosis in alveoli (white arrows) and (E) diffuse
alveolar fibrosis within small airways (arrowhead). (F) The loose myxoid
fibroblastic proliferation extended between the alveoli forming Mason
bodies in alveolar and bronchiolar regions (yellow frame). (G)
Bronchiolitis obliterans organizing pneumonia (BOOP)-like areas (red
frame). (H) The squamous cells formed distinct nodules resembling
squamous morules were noted in COVID-19 patients (blue circles). (I)
Disrupted small blood vessels were also displayed perivascular
fibroblast proliferations (Hash). Scale Bars = 100 μm.