Figure 1. Lung histopathology analyses of COVID-19 patients.
Autopsy lung samples collected from COVID-19 patients show major patterns of (A) widespread diffuse alveolar damage, and (B) fibrosing organizing pneumonia. Fibrotic changes in COVID-19 patients show variable patterns including (C) interstitial fibrotic development (black arrows), (D) intra-alveolar fibrin deposition and organizing fibrosis showing spreading of fibrosis in alveoli (white arrows) and (E) diffuse alveolar fibrosis within small airways (arrowhead). (F) The loose myxoid fibroblastic proliferation extended between the alveoli forming Mason bodies in alveolar and bronchiolar regions (yellow frame). (G) Bronchiolitis obliterans organizing pneumonia (BOOP)-like areas (red frame). (H) The squamous cells formed distinct nodules resembling squamous morules were noted in COVID-19 patients (blue circles). (I) Disrupted small blood vessels were also displayed perivascular fibroblast proliferations (Hash). Scale Bars = 100 μm.