Results
After excluding data that met exclusive criteria, a total of 2340 cases
were included for final analysis.
Among
whom, the number of FGR cases defined by SMFM definition, ACOG
definition and ISUOG definition were 115 (4.9%), 63 (2.7%) and 48
(2.1%) separately. Due to the overlapping of these three definitions,
those FGR cases identified by ACOG and ISUOG were included in the cases
defined by SMFM (Figure 2). Therefore, there were 2225 cases in the
non-FGR group.
As shown in Table 1, the incidences of preeclampsia in the FGR groups
according to different definitions were significantly higher than those
in the non-FGR group (13.91%, 17.46%, 29.17% vs 1.39%), so was the
preterm birth rate (26.96%, 36.51%, 50% vs 6.2%) .
Regarding the neonatal outcomes, there were 147 cases (6.28%) of SGA
newborns. The incidence of SGA in the different FGR groups was
significantly higher than that in the non-FGR group (52.17%, 57.14%,
62.5% vs 3.91%). There were 127 foetus (5.43%) who were complicated
with ANO. The incidence of ANO in the FGR group was higher compared to
the non-FGR group (19.13%, 25.4%, 31.25% vs 4.72%). Likewise, the
incidence of each neonatal complications in the different FGR group were
also higher than that in the non-FGR group (Table 2).
When comparing
the
discriminatory capacities of the three different definitions for
predicting SGA (Table 3), the SMFM criteria had the highest sensitivity
(40.82% vs 24.49%, 20.41%), while the ISUOG criteria had the highest
specificity (99.18% vs 97.49%, 98.77. As for the predictive value for
a composite ANO, it was displayed that all three definitions had low
sensitivity (17.32%, 12.6%, 11.81%) and high specificity of 95.8%,
97.88% and 98.51%.
The
AUCs of SMFM for predicting SGA (0.692) and ANO (0.566) were slightly
higher than those of ACOG (0.616, 0.552) and ISUOG (0.598, 0.552)