Introduction
Granulomatosis with Polyangiitis (GPA) is a small-medium vessel
necrotizing vasculitis and is a component of Anti-Neutrophil Cytoplasmic
Antibody (ANCA) Associated Vasculitides1. It has a
peak incidence at 64 to 75 years of age and is commonly reported in
Caucasians without sex predilection2. Although almost
any organ can be involved in GPA, the upper respiratory tract, lower
respiratory tract, and kidneys are commonly affected3.
The severity of the disease can be heterogeneous. We report a unique
case of granulomatosis with polyangiitis (GPA) in a 26-year-old Asian
female who was initially transferred from an outside hospital due to
shortness of breath presumed to be caused by COVID-19 pneumonia.
However, further evaluation led to the diagnosis of GPA highlighting the
importance of considering GPA in the differential diagnosis, even in
younger individuals and those presenting with respiratory symptoms
suggestive of COVID-19.