3.2.2 Group and sex differences in cocaine cue reactivity and the
relationship with subjective changes in negative affect
Cocaine cues did not induce any significant activation in any of the
ROIs (i.e., DS, VS, amygdala, and dACC), nor was this moderated by group
or sex (see Fig. 2B). These effects did not change upon correcting for
potential confounders (i.e., ADHD, BDI, BIS, CTQ and AUDIT for the group
effects; BIS for the sex effects and BIS, BDI and CTQ for the group by
sex interaction effects). Cocaine-cue induced changes in self-reported
negative affect or craving were not associated with cocaine cue induced
activation in any of the ROIs, nor was this effect moderated by sex
and/or group.