3.2.2 Group and sex differences in cocaine cue reactivity and the relationship with subjective changes in negative affect
Cocaine cues did not induce any significant activation in any of the ROIs (i.e., DS, VS, amygdala, and dACC), nor was this moderated by group or sex (see Fig. 2B). These effects did not change upon correcting for potential confounders (i.e., ADHD, BDI, BIS, CTQ and AUDIT for the group effects; BIS for the sex effects and BIS, BDI and CTQ for the group by sex interaction effects). Cocaine-cue induced changes in self-reported negative affect or craving were not associated with cocaine cue induced activation in any of the ROIs, nor was this effect moderated by sex and/or group.