3.4.1 Emotional cue reactivity
Emotional cues significantly increased activation of various regions in the salience network, including the medial prefrontal cortex, temporal cortex and visual cortex (Table 4, Fig. 4A). There was a significant group by stimulus type interaction effect in the left insula. More specifically, the left insula was more strongly activated by emotional cues in CUs compared to non-CUs (see Fig. 4B). There was also a significant stimulus type by sex interaction effect, demonstrating that the left insula and amygdala were more strongly activated in females compared to males. However, there were no significant sex-dependent differences in the neural correlates of emotional cue-reactivity between CUs and non-CUs.