3.4.1 Emotional cue reactivity
Emotional cues significantly increased activation of various regions in
the salience network, including the medial prefrontal cortex, temporal
cortex and visual cortex (Table 4, Fig. 4A). There was a significant
group by stimulus type interaction effect in the left insula. More
specifically, the left insula was more strongly activated by emotional
cues in CUs compared to non-CUs (see Fig. 4B). There was also a
significant stimulus type by sex interaction effect, demonstrating that
the left insula and amygdala were more strongly activated in females
compared to males. However, there were no significant sex-dependent
differences in the neural correlates of emotional cue-reactivity between
CUs and non-CUs.