Data Analysis
Categorical variables are reported as whole numbers with proportions,
and continuous variables are reported as the median and interquartile
range (IQR), unless indicated otherwise. The Life-time table method was
used to compute the cumulative survival rates and mortality density. Cox
proportional hazard regression models were used to identify the
effectors of mortality and calculate the hazard ratio (HR). Univariable
Cox proportional hazard regression models were implemented first, and
variables with level of significance = 0.10 were included in
multivariable analysis. The results of these models were expressed as
the HR and 95% confidence interval (CI). Statistical analyses were
performed by using SPSS 19.0 (SPSS Inc., Chicago, IL, USA).
The variable with a level of significance = 0.05, identified using
multivariable analysis, served as the explanatory variable for
time-to-death after initiation of second-line ART. The Kaplan-Meier
model was used to estimate the survival and log-rank test were used to
compare survival curves of different groups classified according to the
explanatory variable. Figures showing the survival curves were prepared
using R software (version 3.6.1). Statistical analyses employed
two-sided P <0.05 to indicate a significant difference.