Variables Variables Univariable Univariable Univariable Univariable Univariable Univariable Multivariable Multivariable Multivariable Multivariable Multivariable Multivariable Multivariable
HR(95% CI) HR(95% CI) HR(95% CI) P value P value P value HR(95% CI) HR(95% CI) HR(95% CI) HR(95% CI) HR(95% CI) P value P value
Sex Sex
Male Male 1[Reference] 1[Reference] 1[Reference] NA NA NA 1[Reference] 1[Reference] 1[Reference] 1[Reference] 1[Reference] NA NA
Female Female 0.67(0.57,0.80) 0.67(0.57,0.80) 0.67(0.57,0.80) <0.001 <0.001 <0.001 0.66(0.55,0.79) 0.66(0.55,0.79) 0.66(0.55,0.79) 0.66(0.55,0.79) 0.66(0.55,0.79) <0.001 <0.001
Age(year) Age(year)
40- 40- 1[Reference] 1[Reference] 1[Reference] NA NA NA 1[Reference] 1[Reference] 1[Reference] 1[Reference] 1[Reference] NA NA
40-50 40-50 1.29(0.98,1.70) 1.29(0.98,1.70) 1.29(0.98,1.70) 0.07 0.07 0.07 1.34(1.01,1.76) 1.34(1.01,1.76) 1.34(1.01,1.76) 1.34(1.01,1.76) 1.34(1.01,1.76) 0.06 0.06
50-60 50-60 2.56(1.94,3.38) 2.56(1.94,3.38) 2.56(1.94,3.38) <0.001 <0.001 <0.001 2.69(2.03-3.56) 2.69(2.03-3.56) 2.69(2.03-3.56) 2.69(2.03-3.56) 2.69(2.03-3.56) <0.001 <0.001
Marital Status Marital Status Marital Status Marital Status
Married Married 1[Reference] 1[Reference] 1[Reference] NA NA NA 1[Reference] 1[Reference] 1[Reference] 1[Reference] 1[Reference] NA NA
Sig/window Sig/window 1.41(1.18,1.70) 1.41(1.18,1.70) 1.41(1.18,1.70) <0.001 <0.001 <0.001 1.26(1.04,1.52) 1.26(1.04,1.52) 1.26(1.04,1.52) 1.26(1.04,1.52) 1.26(1.04,1.52) 0.02 0.02
Educational Status Educational Status Educational Status Educational Status Educational Status
≤6years ≤6years 1[Reference] 1[Reference] 1[Reference] NA NA NA 1[Reference] 1[Reference] 1[Reference] 1[Reference] 1[Reference] NA NA
>6years >6years 0.79(0.66,0.95) 0.79(0.66,0.95) 0.79(0.66,0.95) 0.01 0.01 0.01 0.78(0.65,0.94) 0.78(0.65,0.94) 0.78(0.65,0.94) 0.78(0.65,0.94) 0.78(0.65,0.94) 0.01 0.01
Chinese Medicine Therapy Chinese Medicine Therapy Chinese Medicine Therapy Chinese Medicine Therapy Chinese Medicine Therapy
No No 1[Reference] 1[Reference] 1[Reference] NA NA NA 1[Reference] 1[Reference] 1[Reference] 1[Reference] 1[Reference] NA NA
Yes Yes 0.75(0.59,0.95) 0.75(0.59,0.95) 0.75(0.59,0.95) 0.02 0.02 0.02 0.75(0.52,0.96) 0.75(0.52,0.96) 0.75(0.52,0.96) 0.75(0.52,0.96) 0.75(0.52,0.96) 0.02 0.02
CD4+ Cell Count (cells/µl) CD4+ Cell Count (cells/µl) CD4+ Cell Count (cells/µl) CD4+ Cell Count (cells/µl) CD4+ Cell Count (cells/µl)
500+ 500+ 1[Reference] 1[Reference] 1[Reference] NA NA NA 1[Reference] 1[Reference] 1[Reference] 1[Reference] 1[Reference] NA NA
350-500 350-500 1.01(0.73,1.39) 1.01(0.73,1.39) 1.01(0.73,1.39) 0.95 0.95 0.95 1.04(0.76, 1.44) 1.04(0.76, 1.44) 1.04(0.76, 1.44) 1.04(0.76, 1.44) 1.04(0.76, 1.44) 0.80 0.80
200-350 200-350 1.39(1.05,1.84) 1.39(1.05,1.84) 1.39(1.05,1.84) 0.02 0.02 0.02 1.37(1.03,1.82) 1.37(1.03,1.82) 1.37(1.03,1.82) 1.37(1.03,1.82) 1.37(1.03,1.82) 0.03 0.03
200- 200- 1.89(1.44,2.48) 1.89(1.44,2.48) 1.89(1.44,2.48) <0.001 <0.001 <0.001 1.94(1.47,2.55) 1.94(1.47,2.55) 1.94(1.47,2.55) 1.94(1.47,2.55) 1.94(1.47,2.55) <0.001 <0.001
Liver Injury Liver Injury
No No 1[Reference] 1[Reference] 1[Reference] NA NA NA 1[Reference] 1[Reference] 1[Reference] 1[Reference] 1[Reference] NA NA
Yes Yes 1.50(1.13,1.99) 1.50(1.13,1.99) 1.50(1.13,1.99) 0.01 0.01 0.01 1.58(1.19,2.10) 1.58(1.19,2.10) 1.58(1.19,2.10) 1.58(1.19,2.10) 1.58(1.19,2.10) <0.001 <0.001
Unclear Unclear 1.25(1.03,1.51) 1.25(1.03,1.51) 1.25(1.03,1.51) 0.03 0.03 0.03 1.19(0.98,1.45) 1.19(0.98,1.45) 1.19(0.98,1.45) 1.19(0.98,1.45) 1.19(0.98,1.45) 0.08 0.08
Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected Factors Not Selected
HIV transmission mode HIV transmission mode HIV transmission mode HIV transmission mode HIV transmission mode
Others Others 1[Reference] 1[Reference] 1[Reference] NA NA NA NA NA NA NA NA NA NA
Plasma Plasma 1.17(0.93,1.47) 1.17(0.93,1.47) 1.17(0.93,1.47) 0.17 0.17 0.17 NA NA NA NA NA NA NA
Time on HIV positive (year) Time on HIV positive (year) Time on HIV positive (year)
<5 <5 1[Reference] 1[Reference] 1[Reference] NA NA NA NA NA NA NA NA NA NA
5-8 5-8 0.93(0.74,1.18) 0.93(0.74,1.18) 0.93(0.74,1.18) 0.56 0.56 0.56 NA NA NA NA NA NA NA
>8 >8 0.82(0.63,1.08) 0.82(0.63,1.08) 0.82(0.63,1.08) 0.16 0.16 0.16 NA NA NA NA NA NA NA
Time on ART before Second-line (year) Time on ART before Second-line (year) Time on ART before Second-line (year) Time on ART before Second-line (year) Time on ART before Second-line (year)
<3 <3 1[Reference] 1[Reference] 1[Reference] NA NA NA NA NA NA NA NA NA NA
3-6 3-6 0.85(0.67,1.07) 0.85(0.67,1.07) 0.85(0.67,1.07) 0.17 0.17 0.17 NA NA NA NA NA NA NA
>6 >6 0.95(0.77,1.18) 0.95(0.77,1.18) 0.95(0.77,1.18) 0.64 0.64 0.64 NA NA NA NA NA NA NA
Anemia
Yes Yes 1[Reference] 1[Reference] 1[Reference] NA NA NA NA NA NA NA NA NA NA
No No 1.04(0.79,1.37) 1.04(0.79,1.37) 1.04(0.79,1.37) 0.80 0.80 0.80 NA NA NA NA NA NA NA
Unclear Unclear 1.24(0.94,1.62) 1.24(0.94,1.62) 1.24(0.94,1.62) 0.12 0.12 0.12 NA NA NA NA NA NA NA
Hyperlipidemia Hyperlipidemia NA NA NA NA NA NA NA
Yes Yes 1[Reference] 1[Reference] 1[Reference] NA NA NA NA NA NA NA NA NA NA
No No 0.84(0.63,1.12) 0.84(0.63,1.12) 0.84(0.63,1.12) 0.24 0.24 0.24 NA NA NA NA NA NA NA
Unclear Unclear 1.05(0.80,1.39) 1.05(0.80,1.39) 1.05(0.80,1.39) 0.72 0.72 0.72 NA NA NA NA NA NA NA