Mortality and Associated Factors
Among 3331 participants followed for (26988 person-years), 508 (15.3%)
died and the mortality rate was 1.88/100 person-years. Furthermore,
96.8%, 92.7%, 88.9%, 85.5%and 81.2% of participants were alive
after 2, 4, 6, 8 and 10 years, respectively, after the study commenced.
The results of univariable Cox proportional hazards model analyzed
factors associated with mortality of PLHIV were showed in table 2. Age
50-60 years, sig/window, CD4+ T cell count <350 cells/µL, and
liver injury were risk factors of mortality. In contrast, CM therapy,
female, educational status >6years decrease the risk of
mortality. HIV transmission mode, time on HIV-positive, time on ART
before second-line, anemia and hyperlipidemia were not the effected
variable of mortality.
Thus, sex, age, CM
therapy, marital status,
educational status, CD4+ T cell count and liver injury were selected for
multivariable Cox proportional hazards model. This analysis revealed
that female (HR, 0.66; 95%CI, 0.55–0.79), age 50-60 years (HR, 2.69;
95%CI, 2.03–3.56), treated with CM therapy (HR, 0.75; 95%CI,
0.52–0.96), sig/window (HR, 1.26; 95%CI, 1.04–1.52), educational
status >6years (HR, 0.78; 95%CI, 0.65–0.94), liver injury
(HR, 1.58; 95%CI, 1.19–2.10), CD4+ T cell count <200
cells/µl (HR, 1.94; 95%CI, 1.47-2.55), and CD4+ T cell count 200-350
cells/µl (HR, 1.37; 95%CI,
1.03–1.82) were each independently associated with mortality.