Power Estimation for Non-Standardized Multisite Studies

Anisha Keshavan1,21,2Department of Neurology, University California, San Francisco, USA,UC Berkeley - UCSF Graduate Program in Bioengineering, San Francisco, USA Friedemann Paul33NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany. Mona K. Beyer44Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway Alyssa H. Zhu11Department of Neurology, University California, San Francisco, USA Nico Papinutto11Department of Neurology, University California, San Francisco, USA Russell T. Shinohara55Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA William Stern11Department of Neurology, University California, San Francisco, USA Michael Amann66Department of Neurology, Basel University Hospital, Basel, Switzerland Rohit Bakshi77Brigham and Women’s Hospital, MA, United States Antje Bischof1,6,81,6,8Department of Neurology, University California, San Francisco, USA,Department of Neurology, Basel University Hospital, Basel, Switzerland,Clinical Immunology, University Hospital Basel, Switzerland Alessandro Carriero99Department of Translational Medicine, Department of Radiology, UPO University, Via Solaroli 17, 28100, Novara, Italy Manuel Comabella1010Vall d’Hebron Hospital Barcelona, Barcelona, Spain Jason C. Crane1111Department of Radiology and Biomedical Imaging, University California, San Francisco, CA, USA Sandra D’Alfonso1212Department of Health Sciences, UPO University, Novara, Italy Philippe Demaerel1313Department of Radiology, University Hospitals Leuven, Leuven, Belgium Benedicte Dubois1414 KU Leuven – University of Leuven, Department of Neurosciences, Leuven, Belgium Massimo Filippi1515Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University Vinzenz Fleischer1616Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany Bertrand Fontaine1717Hôpital Pitié-Salpêtrière, ICM, UPMC 06 UM 75, INSERM U 1127, CNRS UMR 7225, ICM-A-IHU, AP-HP: Pôle des maladies du système nerveux, 47 boulevard de l’Hôpital, 75013, Paris, France Laura Gaetano6,186,18Department of Neurology, Basel University Hospital, Basel, Switzerland,Medical Image Analysis Center (MIAC AG), Basel, Switzerland. An Goris1414 KU Leuven – University of Leuven, Department of Neurosciences, Leuven, Belgium Christiane Graetz1616Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany Adriane Gröger1616Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany Sergiu Groppa1616Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany David A. Hafler1919Departments of Neurology and Immunobiology, Yale School of Medicine, CT, USA Hanne F. Harbo2020Department of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway Bernhard Hemmer21,2221,22Dept. Neurology of the Klinikum rechts der Isar, Technische Universität München, Munich, Germany,Munich Cluster of Systems Neurology (SyNery) Kesshi Jordan1,21,2Department of Neurology, University California, San Francisco, USA,UC Berkeley - UCSF Graduate Program in Bioengineering, San Francisco, USA Ludwig Kappos66Department of Neurology, Basel University Hospital, Basel, Switzerland Gina Kirkish1111Department of Radiology and Biomedical Imaging, University California, San Francisco, CA, USA Sara Llufriu2323Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain Stefano Magon66Department of Neurology, Basel University Hospital, Basel, Switzerland Filippo Martinelli-Boneschi1515Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University Jacob McCauley2424John P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, USA Xavier Montalban1010Vall d’Hebron Hospital Barcelona, Barcelona, Spain Mark Mühlau21,2521,25Dept. Neurology of the Klinikum rechts der Isar, Technische Universität München, Munich, Germany,TUM–Neuroimaging Center, Technische Universität München, Germany Daniel Pelletier1919Departments of Neurology and Immunobiology, Yale School of Medicine, CT, USA Pradip M. Pattany2424John P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, USA Margaret Pericak-Vance2424John P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, USA Isabelle Rebeix1717Hôpital Pitié-Salpêtrière, ICM, UPMC 06 UM 75, INSERM U 1127, CNRS UMR 7225, ICM-A-IHU, AP-HP: Pôle des maladies du système nerveux, 47 boulevard de l’Hôpital, 75013, Paris, France Maria Rocca1515Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University Alex Rovira1010Vall d’Hebron Hospital Barcelona, Barcelona, Spain Regina Schlaeger1,6,81,6,8Department of Neurology, University California, San Francisco, USA,Department of Neurology, Basel University Hospital, Basel, Switzerland,Clinical Immunology, University Hospital Basel, Switzerland Albert Saiz2323Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain Till Sprenger6,266,26Department of Neurology, Basel University Hospital, Basel, Switzerland,DKD Helios Klinik Wiesbaden, Wiesbaden, Germany Alessandro Stecco2727Section of Neuroradiology, Department of Radiology, Maggiore Hospital, Novara, Italy, Corso Mazzini 18, 28100 Bernard M.J. Uitdehaag2828MS Center Amsterdam, VU University Medical Center Amsterdam,The Netherlands Pablo Villoslada2323Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain Mike P. Wattjes2828MS Center Amsterdam, VU University Medical Center Amsterdam,The Netherlands Howard Weiner77Brigham and Women’s Hospital, MA, United States Jens Wuerfel3,293,29NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany.,Medical Image Analysis Center Basel, Switzerland Claus Zimmer3030Dept. Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany Frauke Zipp1616Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany International Multiple Sclerosis Genetics Consortium3131International Multiple Sclerosis Genetics Consortium Stephen Hauser11Department of Neurology, University California, San Francisco, USA Jorge R. Oksenberg1