3.1 Adult PBPK model verification
The comparison between the simulated PK of orally administered CAB, RPV and RAL in adults against their respective observed clinical data are shown in table 3. The absolute average fold error (AAFE) values of the simulated vs observed PK parameters were all less than 2-fold which was the accepted threshold for this study. Likewise, the simulated PK of LAI CAB and LAI RPV in adults were compared against their corresponding clinical data as shown in table 4 with the AAFE yielding values below 2-fold. Thus, the adult PBPK models were considered qualified and suitable for investigating the PK of oral CAB, RPV and RAL in novel clinical scenarios. The same also applied for the suitability of the adult PBPK model to evaluate the PK of LAI CAB and LAI RPV in adults.