PK parameter Observed Simulated AAFE
30 mg CAB (single dose)# [42]
Cmax (µg/ml) 3.61 3.07 1.18
AUC0-inf (µg.h/ml) 146 98.2 1.49
30 mg CAB (repeated doses)# [34]
Ctrough (µg/ml) 4.9 4.6 1.06
Cmax (µg/ml) 8.3 7.8 1.06
AUC0-24 (µg.h/ml) 147 154 1.05
25 mg RPV (repeated doses)^ [43]
Cmin (ng/mL) 89.85 68.9 1.30
Cmax (ng/mL) 203.8 219.75 1.08
AUC0-24 (ng.h/mL) 2589 3304.9 1.28
25 mg RPV (repeated doses)^ [45]
Ctrough (ng/mL) 67.3 62.2 1.08
Cmax (ng/mL) 180.9 189.60 1.05
AUC0-24 (ng.h/mL) 2528 2895.7 1.15
25 mg RPV (repeated doses)# [44]
Ctrough (ng/mL) 74.5 62.7 1.19
Cmax (ng/mL) 148 176.01 1.19
AUC0-24 (ng.h/mL) 2227 2779.8 1.25
25 mg RPV (repeated doses)# [44]
Ctrough (ng/mL) 87.4 66.7 1.31
Cmax (ng/mL) 171 177.68 1.04
AUC0-24 (ng.h/mL) 2473 2860.3 1.16
150 mg RPV (repeated doses)^ [46]
Ctrough (ng/mL) 478 400.6 1.19
Cmax (ng/mL) 1123 1296 1.15
AUC0-24 (ng.h/mL) 16051 19398 1.21
400 mg RAL (repeated doses)# [47]
Ctrough (ng/ml) 48.84 44.71 1.09
Cmax (ng/ml) 1203 1749 1.45
AUC0-12 (ng.h/ml) 4440 8530 1.92
400 mg RAL (single dose)# [48]
Ctrough (ng/ml) 35.79 65.65 1.83
Cmax (ng/ml) 1279 1631 1.28
AUC0-inf (ng.h/ml) 4884 8406 1.72