|
Observed* |
Simulated |
Simulated |
AAFE |
Observed#
|
Simulated |
Simulated |
AAFE |
Observed#
|
Simulated |
AAFE |
CAB |
|
|
|
|
|
|
|
|
|
|
|
800 mg IM + 200 mg IM monthly |
1.61 |
1.68 |
1.68 |
1.04 |
2.2 |
2.0 |
2.0 |
1.09 |
1242 |
1255 |
1.01 |
800 mg IM + 400 mg IM monthly |
3.27 |
2.71 |
2.71 |
1.21 |
4.4 |
3.3 |
3.3 |
1.35 |
2473 |
2020 |
1.22 |
800 mg IM quarterly |
1.1 |
1.4 |
1.4 |
1.26 |
3.3 |
2.6 |
2.6 |
1.27 |
4467 |
3947 |
1.27 |
|
Cτ (ng/ml) |
Cτ
(ng/ml) |
Cmax (ng/ml) |
Cmax (ng/ml) |
Cmax
(ng/ml) |
Cmax (ng/ml) |
AUC0-τ (ng.h/ml) |
AUC0-τ (ng.h/ml) |
AUC0-τ (ng.h/ml) |
AUC0-τ (ng.h/ml) |
AUC0-τ (ng.h/ml) |
|
Observed* |
Simulated |
Simulated |
AAFE |
Observed#
|
Simulated |
Simulated |
AAFE |
Observed#
|
Simulated |
AAFE |
RPV |
|
|
|
|
|
|
|
|
|
|
|
1200 mg IM + 600 mg IM monthly |
78.9 |
109.4 |
109.4 |
1.39 |
126 |
143 |
143 |
1.13 |
63656 |
84685 |
1.33 |
1200 mg IM + 900 mg IM monthly |
79.1 |
132.8 |
132.8 |
1.68 |
168 |
173 |
173 |
1.03 |
74420 |
102489 |
1.38 |