CAB – cabotegravir, RAL – raltegravir, RPV - rilpivirine, pKa - acid dissociation constant, R - blood-to-plasma drug ratio, Log Po:w - partition coefficient between octanol and water, fup - fraction of drug unbound in plasma, HBD - number of hydrogen bond donors, PSA - polar surface area, Papp- apparent permeability coefficient, Clint - intrinsic clearance, CYP - cytochrome P450, UGT - uridine diphosphate-glucuronosyltransferase.
aµL/min/106 hepatocytes.
bvalue fitted in the model using available clinical PK data.
Table 2: Key pregnancy-induced anatomical, physiological, and metabolic changes implemented in the pregnancy model