Data presented as geometric mean values.# Clinical data observed by Spreen et al 2014 [34]. AAFE – absolute average fold error; Cτ – plasma concentration at the end of the dosing interval, Cmax – maximum plasma concentration, AUC0-τ – area under the plasma concentration time curve within the dosing interval, IM – intramuscular.
Table 5: Qualification of pregnancy PBPK model for oral PK of RAL and RPV in pregnant women (simulated vs observed)