PK parameter Observed Simulated AAFE
RAL
2nd trimester‡a
C12 (ng/ml) 62.1 34 1.81
Cmax (ng/ml) 2250 1386 1.62
AUC0-12 (ng.h/ml) 6600 6622 1.00
3rd trimester‡a
C12 (ng/ml) 64 36 1.78
Cmax (ng/ml) 1770 1458 1.21
AUC0-12 (ng.h/ml) 5400 7084 1.31
3rd trimester^b
C12 (ng/ml) 77 42 1.84
Cmax (ng/ml) 1430 1515 1.06
AUC0-inf (ng.h/ml) 5000 7366 1.47
RPV
2nd trimester#c
Cmin (ng/ml) 54.3 30.2 1.80
Cmax (ng/ml) 121 166 1.37
AUC0-24 (ng.h/ml) 1792 2226 1.24
3rd trimester#c
Cmin (ng/ml) 52.9 36.5 1.45
Cmax (ng/ml) 123 177 1.44
AUC0-24 (ng.h/ml) 1762 2456 1.39
3rd trimester^d
Cmin (ng/ml) 50 33 1.50
Cmax (ng/ml) 110 170 1.57
AUC0-24 (ng.h/ml) 1710 2400 1.39