CAB – cabotegravir, RAL – raltegravir, RPV - rilpivirine, pKa - acid
dissociation constant, R - blood-to-plasma drug ratio, Log
Po:w - partition coefficient between octanol and water,
fup - fraction of drug unbound in plasma, HBD - number
of hydrogen bond donors, PSA - polar surface area, Papp- apparent permeability coefficient, Clint - intrinsic
clearance, CYP - cytochrome P450, UGT - uridine
diphosphate-glucuronosyltransferase.
aµL/min/106 hepatocytes.
bvalue fitted in the model using available clinical PK
data.
Table 2: Key pregnancy-induced anatomical, physiological, and metabolic
changes implemented in the pregnancy model