Median values. ^Geometric mean values. #Arithmetic mean values. RAL – raltegravir, RPV - rilpivirine, AAFE – absolute average fold error, C12 – plasma concentration 12 hrs after dose administration, Cmin – minimum plasma concentration, Cmax – maximum plasma concentration, AUC0-inf – area under the plasma plasma concentration time curve till infinity, AUC0-12 – area under the plasma plasma concentration time curve within 12 hours, AUC0-24 – area under the plasma plasma concentration time curve within 24 hours.
aWatts et al 2014 [52]; bBlonk et al 2015 [51]; cOsiyemi et al 2018 [21];dSchalkwijk et al 2017 [41]
Table S1: Simulated PK parameters for monthly and bimonthly dosing of LAI CAB and LAI RPV (without oral lead-in component) at week 12 in pregnant and non-pregnant women.