CAB 600mg then 400mg monthly (n=400) CAB 600mg then 400mg monthly (n=400) CAB 600mg then 400mg monthly (n=400) CAB 600mg bimonthly# (n=400) CAB 600mg bimonthly# (n=400) CAB 600mg bimonthly# (n=400) RPV 900mg then 600mg monthly (n=400) RPV 900mg then 600mg monthly (n=400) RPV 900mg then 600mg monthly (n=400) RPV 900mg bimonthly# (n=400) RPV 900mg bimonthly# (n=400) RPV 900mg bimonthly# (n=400)
Ctrough (μg/ml) Cmax (μg/ml) AUC0-672 (μg.hr/mL) Ctrough (μg/ml) Cmax (μg/ml) AUC0-1344 (μg.hr/mL) Ctrough (ng/mL) Cmax (ng/mL) AUC0-672 (ng.hr/mL) Ctrough (ng/mL) Cmax (ng/mL) AUC0-1344 (ng.hr/mL)
Non-pregnant Adults Geometric mean 2.20 2.65 1632 1.70 2.57 2857 Geometric mean 101 131 78250 76 134 139428
SD 0.37 0.44 275 0.28 0.41 464 SD 19 25 14900 15 25 26611
% Ctrough <0.664 μg/ml 0 - - 0 - - % Ctrough <50 ng/ml 0 - - 0.8 - -
% Ctrough <70 ng/ml 1.8 - - 33.3 - -
First trimester Geometric mean 1.83 2.29 1386 1.44 2.38 2546 Geometric mean 86 113 66692 65 116 119368
SD 0.30 0.36 222 0.23 0.37 405 SD 9 12 7074 7 12 12220
% Ctrough <0.664 μg/ml 0 - - 0 - - % Ctrough <50 ng/ml 0 - - 1 - -
% Ctrough <70 ng/ml 3.3 - - 81.5 - -
Second trimester Geometric mean 1.71 2.07 1273 1.33 2.05 2246 Geometric mean 82 109 64169 62 112 114661
SD 0.30 0.35 217 0.22 0.33 366 SD 9 12 6917 7 12 12103
% Ctrough <0.664 μg/ml 0 - - 0 - - % Ctrough <50 ng/ml 0 - - 0.5 - -
% Ctrough <70 ng/ml 5.8 - - 89.3 - -
CAB 600mg then 400mg monthly (n=400) CAB 600mg then 400mg monthly (n=400) CAB 600mg then 400mg monthly (n=400) CAB 600mg bimonthly# (n=400) CAB 600mg bimonthly# (n=400) CAB 600mg bimonthly# (n=400) RPV 900mg then 600mg monthly (n=400) RPV 900mg then 600mg monthly (n=400) RPV 900mg then 600mg monthly (n=400) RPV 900mg bimonthly# (n=400) RPV 900mg bimonthly# (n=400) RPV 900mg bimonthly# (n=400)
Ctrough (μg/ml) Cmax (μg/ml) AUC0-672 (μg.hr/mL) Ctrough (μg/ml) Cmax (μg/ml) AUC0-1344 (μg.hr/mL) Ctrough (ng/mL) Cmax (ng/mL) AUC0-672 (ng.hr/mL) Ctrough (ng/mL) Cmax (ng/mL) AUC0-1344 (ng.hr/mL)
Third trimester Geometric mean 2.12 2.36 1500 1.62 2.12 2486 Geometric mean 83 108 63975 63 110 113969
SD 0.37 0.40 257 0.28 0.35 418 SD 9 12 7148 7 12 12467
% Ctrough <0.664 μg/ml 0 - - 0 - - % Ctrough <50 ng/ml 0 - - 2.3 - -
% Ctrough <70 ng/ml 5.5 - - 81 - -