Parameter Equation Reference
Body weight (kg) Body weight = 61.1 + 0.2409GA + 0.0038GA2 [17]
Cardiac output (L/h) Cardiac output = 301 + 5.916GA - 0.088GA2 [17]
Plasma proteins (g/L) Plasma proteins = 69.7 + 0.2085GA - 0.0305GA2 + 0.0006GA3 [17]
CYP3A4 enzyme activity CYP3A4 activity = 100 + 2.9826GA - 0.0741GA2 [17]
UGT1A1 enzyme activity UGT1A1 activity = 100 + 2.9826GA - 0.0741GA2 [17, 18]