References
[1] Ni, H. M., Williams, J. A., Ding, W. X., Mitochondrial dynamics and mitochondrial quality control. Redox Biol 2015, 4 , 6-13.
[2] Stehling, O., Lill, R., The role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseases. Cold Spring Harb Perspect Biol 2013, 5 , a011312.
[3] Zhao, R. Z., Jiang, S., Zhang, L., Yu, Z. B., Mitochondrial electron transport chain, ROS generation and uncoupling (Review).Int J Mol Med 2019, 44 , 3-15.
[4] Deshpande, O. A., Mohiuddin, S. S., Biochemistry, Oxidative Phosphorylation, StatPearls , Treasure Island (FL) 2022.
[5] Boyman, L., Karbowski, M., Lederer, W. J., Regulation of Mitochondrial ATP Production: Ca(2+) Signaling and Quality Control.Trends Mol Med 2020, 26 , 21-39.
[6] Nath, S., Integration of demand and supply sides in the ATP energy economics of cells. Biophys Chem 2019, 252 , 106208.
[7] Gorman, G. S., Chinnery, P. F., DiMauro, S., Hirano, M., et al. , Mitochondrial diseases. Nat Rev Dis Primers 2016,2 , 16080.
[8] Balsa, E., Perry, E. A., Bennett, C. F., Jedrychowski, M., et al. , Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death. Nat Commun 2020, 11 , 2714.
[9] Warburg, O., On respiratory impairment in cancer cells.Science 1956, 124 , 269-270.
[10] Lissanu Deribe, Y., Sun, Y., Terranova, C., Khan, F., et al. , Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med 2018,24 , 1047-1057.
[11] Goodman, A., Mahmud, W., Buckingham, L., Gene variant profiles and tumor metabolic activity as measured by FOXM1 expression and glucose uptake in lung adenocarcinoma. J Pathol Transl Med 2020,54 , 237-245.
[12] Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., et al. , Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle2011, 10 , 4047-4064.
[13] Viale, A., Pettazzoni, P., Lyssiotis, C. A., Ying, H., et al. , Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 2014, 514 , 628-632.
[14] Reznik, E., Miller, M. L., Senbabaoglu, Y., Riaz, N., et al. , Mitochondrial DNA copy number variation across human cancers.Elife 2016, 5 .
[15] Weinberg, S. E., Chandel, N. S., Targeting mitochondria metabolism for cancer therapy. Nat Chem Biol 2015, 11 , 9-15.
[16] Wheaton, W. W., Weinberg, S. E., Hamanaka, R. B., Soberanes, S., et al. , Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife 2014, 3 , e02242.
[17] Preble, J. M., Pacak, C. A., Kondo, H., MacKay, A. A., et al. , Rapid isolation and purification of mitochondria for transplantation by tissue dissociation and differential filtration.J Vis Exp 2014, e51682.
[18] Langen, P., Hucho, F., Karl Lohmann and the discovery of ATP.Angew Chem Int Ed Engl 2008, 47 , 1824-1827.
[19] Sun, L., Zhang, L., Chen, J., Li, C., et al. , Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma. Cancer Res Treat 2020, 52 , 604-621.
[20] Gatt, A. P., Duncan, O. F., Attems, J., Francis, P. T., et al. , Dementia in Parkinson’s disease is associated with enhanced mitochondrial complex I deficiency. Mov Disord 2016, 31 , 352-359.
[21] Kurelac, I., MacKay, A., Lambros, M. B., Di Cesare, E., et al. , Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas. Hum Mol Genet 2013, 22 , 226-238.
[22] Astuti, D., Latif, F., Dallol, A., Dahia, P. L., et al. , Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet 2001, 69 , 49-54.
[23] Bandara, A. B., Drake, J. C., Brown, D. A., Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog. BMC Mol Cell Biol2021, 22 , 35.
[24] Brand, M. D., Nicholls, D. G., Assessing mitochondrial dysfunction in cells. Biochem J 2011, 435 , 297-312.
[25] Dranka, B. P., Hill, B. G., Darley-Usmar, V. M., Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free Radic Biol Med 2010, 48 , 905-914.
[26] Pesta, D., Gnaiger, E., High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 2012, 810 , 25-58.
[27] Tarjan, E. M., Von Korff, R. W., Factors affecting the respiratory control ratio of rabbit heart mitochondria. J Biol Chem 1967, 242 , 318-324.
[28] Salin, K., Auer, S. K., Rey, B., Selman, C., Metcalfe, N. B., Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance. Proc Biol Sci 2015,282 , 20151028.
[29] Szostaczuk, N., van Schothorst, E. M., Sanchez, J., Priego, T., et al. , Identification of blood cell transcriptome-based biomarkers in adulthood predictive of increased risk to develop metabolic disorders using early life intervention rat models.FASEB J 2020, 34 , 9003-9017.
[30] Tomas, C., Brown, A., Strassheim, V., Elson, J. L., et al. , Cellular bioenergetics is impaired in patients with chronic fatigue syndrome. PLoS One 2017, 12 , e0186802.
[31] Hartman, M. L., Shirihai, O. S., Holbrook, M., Xu, G., et al. , Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus.Vasc Med 2014, 19 , 67-74.
[32] Diaz-Rua, R., Keijer, J., Caimari, A., van Schothorst, E. M., et al. , Peripheral blood mononuclear cells as a source to detect markers of homeostatic alterations caused by the intake of diets with an unbalanced macronutrient composition. J Nutr Biochem2015, 26 , 398-407.
[33] Reynes, B., Klein Hazebroek, M., Garcia-Ruiz, E., Keijer, J., et al. , Specific Features of the Hypothalamic Leptin Signaling Response to Cold Exposure Are Reflected in Peripheral Blood Mononuclear Cells in Rats and Ferrets. Front Physiol 2017,8 , 581.
[34] Rai, N. K., Mathur, S., Singh, S. K., Tiwari, M., et al. , Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells.Oncol Lett 2020, 20 , 313.