3.2 Clinical characteristics comparison between VaIN1 and VaIN2+
The median age of VaIN2+ patients was 53 years (range: 42-59.25 years)which was older than that of VaIN1 patients with a median age of 41.5 years (range: 32-52 years) (p<0.001). Moreover, VaIN2+ patients were more likely to have concomitant cervical lesions (67.7% vs. 46.2%, p<0.001), higher gravidity (p=0.021) and parity (p<0.001) compared to VaIN1 patients. There were also more post-menopausal women in VaIN2+ group the VaIN1 group (52.3% vs. 24.8%, p<0.001). The hr-HPV positive rate among VaIN2+ patients was higher than VaIN1 patients (95.4% vs.86.8%, p<0.001), with HPV16/18 detected more frequently in VaIN2+ patients(62.2%) than in VaIN1 patients (27.9%) (p<0.001).There was no statistically significant difference in single and multiple hr-HPV infections between VaIN1 and VaIN2+ patients. VaIN1 group was more likely to have a history of low-grade cervical intraepithelial neoplasia than VaIN2 group (6.9% vs. 3.0%, p<0.001), while VaIN2 group was more likely to have a history of high-grade cervical intraepithelial neoplasia than VaIN1 group (29.3% vs. 14.4%, p<0.001). Furthermore, ASCUS and LSIL were more frequantly detected in VaIN1 patients, while ASC-H\HSIL\SCC\AGC were more likely to be detected in VaIN2 patients, the difference is statistically significant (p<0.001) (Table 2). Additionally, the analysis showed a weak correlation between vaginal and cervical lesions (Kendall’s Tau correlation=0.387, p<0.001).
[insert Table 2]