2.1 Study Population
This study included patients with a definitive histopathologic diagnosis
of VaIN who were referred for colposcopy from February 2013 to November
2022 at the Cervical Disease Diagnosis and Treatment Health Center at
Fujian Maternity and Child Health Hospital dueto abnormal cytology
results and/or a positive hr-HPV test, and underwent biopsy from
suspicious regions. The pathological diagnosis of tissue and cytology
specimens were independently performed by two senior pathologists. The
interval between cytological tests/ HPV test and colposcopy were all
less than 3 months. Patients with a history of VaIN or cervical cancer
metastasis were excluded from the study. Clinical information, including
age, gravidity, parity, HPV genotypes, cytology results, cervical lesion
history, hysterectomy history cervical pathology and vaginal pathology,
was obtained from the medical records of the department.
This study was conducted in compliance with the Declaration of Helsinki
(as revised in 2013) and was endorsed by the Ethics Committee at Fujian
Maternity and Child Health Hospital, Affiliated Hospital of Fujian
Medical University (2023KY003). An exemption of informed consent was
obtained considering the retrospective nature of the study.