3.4 Comparison of the sensitivity of cervical cancer screening against VaIN and CIN
The sensitivities of cytology, hr-HPV and cotesting is displayed in Table 3. Among patients without total hysterectomy, cytology had a sensitivity of 84.9% for VaIN2+, which was slightly lower than the sensitivity of 87.4% for CIN2+; however, this difference was not statistically significant (P=0.495). The sensitivities of hr-HPV testing for detecting VaIN2+ and CIN2+ were 95.0% and 96.7%, respectively (P=0.480). The cotesting sensitivities for detecting VaIN2+, CIN2+, and VaIN2+ after hysterectomy were all 100%. The sensitivity of hr-HPV testing for detecting VaIN2+ was significantly higher than that of cytology (95.4% vs. 88.1%, p=0.007). However, there was no statistical difference between the two tests for detecting VaIN2+ after hysterectomy (97.1% vs. 96.4%, p=0.829).
[insert Table 3]