Comparison of baseline characteristics of RSA patients and normal pregnant women with different ATA
In the overall population, there were 1068 study subjects, of whom 402 (37.6%) were RSA patients, and 666 (62.4%) were normal pregnant women. Among the study subjects, 253 (23.7%) tested positive for Anti-TPO, and 273 (25.6%) tested positive for Anti-TG, with a higher proportion of individuals testing negative for both antibodies. The correlation between variables and RSA in the overall population is presented in Supplementary Table S1. ADP, AA, R, K, CI, EPL, and LY30 did not show statistical significance, while the remaining variables demonstrated statistical significance.
Table 1 and Table 2 demonstrate the baseline characteristics of RSA patients versus normal pregnant women. In terms of plasma TAFI levels, all groups, regardless of the status of antibodies, exhibited significantly lower levels in RSA patients compared to normal pregnant women with statistical significance. The median TAFI level in normal pregnant women was approximately 25 ug/mL, which was about 2 ug/mL higher than that of RSA patients. Interestingly, the Anti-TPO negative group had higher levels of plasma TAFI compared to the Anti-TPO positive group in both cases and controls.
Regarding the age of the study population, the results of both tables indicated that RSA patients were older than normal pregnant women. However, statistically significant differences were observed only in the Anti-TPO negative and Anti-TG positive groups. With regards to the platelet aggregation function indicators (ADP and AA), Only AA showed statistically significant in the Anti-TG negative group.
With regard to coagulation, the results were similar across antibody states. In the Anti-TPO negative and Anti-TG negative groups, all coagulation parameters (PT, PTA, APTT, FIB, TT, DD) showed statistically significant differences.
Concerning blood cell tests and thyroid function, the results of the analysis were the same in the two negative groups, and the analysis of the results was similar in the two positive groups. In both negative groups, except for MONO, all blood cell tests (LYMPH, MONO, BASO, RDW-CV, RDW-SD) and thyroid function indicators (FT3, FT4, TSH) showed statistically significant differences. In both positive groups, LYMPH showed statistical differences in both groups. BASO showed statistical differences only in the Anti-TPO positive group, while FT3 showed statistical differences only in the Anti-TG positive group.
On the aspect of thromboelastography indexes, the results of the analysis of the two positive groups were the same as those of the two negative groups. Only LY30 was statistically different in the two positive groups. In both the Anti-TPO negative and Anti-TG negative groups, Angle and MA showed statistically significant differences.