Study population and data source
We conducted a retrospective case-control study to investigate the effect of TAFI on RSA in Anti-TPO, Anti-TG negative, and positive pregnant women, using gestational examination data from January 2020 to March 2022 from the Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University. We defined RSA as the occurrence of two or more miscarriages with the same partner before 24 weeks of gestation. All patients underwent a standardized diagnostic protocol, and those who received a confirmed diagnosis of RSA by the hospital were included in this study. Ultimately, we included 402 patients with RSA and 666 normal pregnant women. The study was approved by the Ethics Committee of Shengjing Hospital, China Medical University.