Prediction of binding affinity of peptides to
TAP
Peptides must be transported to the endoplasmic reticulum before they
can be presented to CD4+ cells by MHC-I. TAP protein carries out the
transport process, so the TAP affinities of the eight amino acid length
peptides were evaluated and shown in Table-3.
Allergenicity
prediction
The identical peptides allergenicity predicted in AllerTOP v2.0
bioinformatic tool and shown in Table-3. Identical epitopes causing
autoimmunity should not necessarily be allergic.
Toxicity prediction
The identical peptides must be non-toxic to the human body. For
prediction of toxicity, the ToxinPred tool used for toxicity prediction
results is shown in Table-3.
Table-3
Evaluation of the transport efficiency through to TAP protein complex
involved in antigen presentation, allergenicity, and toxicity of 8mer
sequences posessing molecular mimicry.