CONCLUSIONS
Knowledge of redox energetics of oxidoreductases is critical to
understanding metabolic function and evolution. ProtReDox is intended to
be a valuable tool in this regard as we and others contribute to its
growth. Currently, the size of ProtReDox limits the extent to which
structure-based predictive models can be trained on redox energetics.
However, with further experimental investigations and as high-quality
models of protein structures become readily accessible, these models
should improve. This would allow more complete mapping of data
structures such as the SpAN, providing a greater understanding of the
evolution of redox energetics in metabolism through time.