3.4. SCH and TEWL levels
In lesional skins, TEWL levels (20.7 ± 8.6 g/m2/hr) were significantly higher and SCH levels (25.7 ± 18.2 a.u.) were significantly lower than those in non-lesional skins (13.3 ± 8.7 g/m2/hr and 41.9 ± 15.1 a.u, respectively, p< 0.001 for both) (Figure S1).
In lesional or non-lesional skin, SCH levels were significantly lower in children with moderate-severe AD (38.0 ± 16.1 and 19.8 ± 15.6, respectively) than in children with mild AD (47.7 ± 11.3 and 34.4 ± 18.5, respectively; p < 0.001 for both) (Table 3). Although TEWL levels in children with moderate-severe AD tended to be higher than those in children with mild AD, the differences were not statistically significant.