Table 1: Baseline characteristics of the SARS Cov-2 PCR positive
pediatric cohort
Figure 1: Respiratory and serum samples collected between
November 2020 to August 2021. X-axis represents month and year. Y-axis
represents number of respiratory (upper pane) or serum (lower pane)
samples per month. Wild-type (including Wu Hu-1,D614G variants) and
Delta (B.1.617.2) waves based on sequencing data. Blood collected 4-6
weeks after respiratory sample.
Figure 2: SARS CoV-2 anti-nucleoprotein and anti-spike antibody
levels across viral load strata. A) Levels of SARS CoV-2 anti-N and
Anti-S antibody in different Ct quartiles - Q1(teal), Q2(pink),Q3 (blue)
and Q4 (brown) of either anti-N or anti-S antibody indicated by
brackets. Y-axis shows levels of antibodies (cut-off index (CoI) for
anti-N or Units/ml for anti-S). B) Comparison of levels of anti-S
antibody across viral load quartiles(Q1-Q4) in Wild type and Delta
infected. X-Axis shows different quartiles (Q1-Q4) of either wild-type
(green bars) or Delta (Red bars). Y-axis shows levels of anti-S
antibodies in U /ml. Level of statistical significance is denoted by *
for p <0.05, ** for p < 0.01, *** for p <
0.001, ****for p < 0.0001, not significant
(p>0.05) if not indicated.
Figure 3: SARS CoV-2 Ct value of Wild-type and
Delta-infected respiratory samples across clinical severity. X-axis
represents strata (asymptomatic, mild-to-moderate or severe); Y-axis
denotes Ct value. Each sample represented by a dot
coloured as green (wild-type) or red (Delta). Mean Ct of
each group indicated by black line for each severity strata with SD
denoted by error bars. Level of statistical significance is denoted by *
for p <0.05, ** for p < 0.01, *** for p <
0.001, ****for p < 0.0001, not significant
(p>0.05) if not indicated.
Figure 4: SARS CoV-2 anti-nucleoprotein and anti-spike antibody
levels across clinical severity. A) Levels of anti-N (purple) and anti-S
antibody (lavender) in the entire cohort across clinical severity. B)
Levels of anti-N and anti-S antibody in delta-infected children across
clinical severity. X-axis represents strata (asymptomatic,
mild-to-moderate or severe); Y-axis shows antibody levels (CoI for
anti-N or Units/ml for anti-S). Level of statistical significance is
denoted by * for p <0.05, ** for p < 0.01, *** for p
< 0.001, ****for p < 0.0001, ns for not significant
(p>0.05) .