Patients and OS samples
A series of 20 surgically resected fresh human OS and corresponding
adjacent nontumor tissue samples were collected at the First Affiliated
Hospital of Zhengzhou University (Zhengzhou, China) and snap-frozen in
liquid nitrogen from July 2018 to January 2019. Among them, 3 pairs were
used for circRNA microarray analysis. No patients had received any
preoperative treatment. Clinical data of patients included in this study
are detailed in Supplementary Table 1. Samples used in this study were
approved by the Committees for Ethical Review of the First Affiliated
Hospital of Zhengzhou University.