\documentclass[10pt]{article}

\usepackage{fullpage}
\usepackage{setspace}
\usepackage{parskip}
\usepackage{titlesec}
\usepackage[section]{placeins}
\usepackage{xcolor}
\usepackage{breakcites}
\usepackage{lineno}
\usepackage{hyphenat}





\PassOptionsToPackage{hyphens}{url}
\usepackage[colorlinks = true,
            linkcolor = blue,
            urlcolor  = blue,
            citecolor = blue,
            anchorcolor = blue]{hyperref}
\usepackage{etoolbox}
\makeatletter
\patchcmd\@combinedblfloats{\box\@outputbox}{\unvbox\@outputbox}{}{%
  \errmessage{\noexpand\@combinedblfloats could not be patched}%
}%
\makeatother


\usepackage{natbib}




\renewenvironment{abstract}
  {{\bfseries\noindent{\abstractname}\par\nobreak}\footnotesize}
  {\bigskip}

\titlespacing{\section}{0pt}{*3}{*1}
\titlespacing{\subsection}{0pt}{*2}{*0.5}
\titlespacing{\subsubsection}{0pt}{*1.5}{0pt}


\usepackage{authblk}


\usepackage{graphicx}
\usepackage[space]{grffile}
\usepackage{latexsym}
\usepackage{textcomp}
\usepackage{longtable}
\usepackage{tabulary}
\usepackage{booktabs,array,multirow}
\usepackage{amsfonts,amsmath,amssymb}
\providecommand\citet{\cite}
\providecommand\citep{\cite}
\providecommand\citealt{\cite}
% You can conditionalize code for latexml or normal latex using this.
\newif\iflatexml\latexmlfalse
\providecommand{\tightlist}{\setlength{\itemsep}{0pt}\setlength{\parskip}{0pt}}%

\AtBeginDocument{\DeclareGraphicsExtensions{.pdf,.PDF,.eps,.EPS,.png,.PNG,.tif,.TIF,.jpg,.JPG,.jpeg,.JPEG}}

\usepackage[utf8]{inputenc}
\usepackage[greek,english]{babel}



\usepackage{float}








\begin{document}

\title{Case Report: Kasabach-Merritt phenomenon in a 7-month-old Cambodian
infant}



\author[1]{Vireak Prom}%
\author[2]{Chinith Phauk}%
\author[2]{Angkeabos Nhep}%
\author[1]{Sandro Vento}%
\affil[1]{University of Puthisastra}%
\affil[2]{National Pediatric Hospital}%


\vspace{-1em}



  
  \date{June 15, 2024}


\begingroup
\let\center\flushleft
\let\endcenter\endflushleft
\maketitle
\endgroup





\selectlanguage{english}
\begin{abstract}
Introduction. Kasabach-Merritt phenomenon (KMP) is a rare condition
associated with vascular tumors such as kaposiform hemangioendothelioma
and tufted angioma; it can be life threatening, due to its consumptive
coagulopathy. Thrombocytopenia and hypofibrinogenemia are characteristic
of KMP, and anemia and raised d-dimer levels can also be detected. Here,
we report a 7-month-old Cambodian with the condition. Case Presentation.
The infant was admitted to the National Pediatric Hospital in Phnom Penh
because of a mass on the right side of the neck that had been
progressively enlarging. The patient had severe thrombocytopenia
(8,000/\selectlanguage{greek}µ\selectlanguage{english}L), anemia (Hb 7.6g/dL) and reduced fibrinogen level (1.5g/L).
CT scan and histology of the lesion confirmed a diagnosis of hemangioma.
Kasabach-Merritt phenomenon was diagnosed, and the infant was treated
with platelets and fresh frozen plasma infusions, prednisolone
(2mg/kg/day) and propranolol (2.5mg/kg/day). After eight weeks of
therapy, platelets raised to 102,000/\selectlanguage{greek}µ\selectlanguage{english}L. The infant developed Cushing's
syndrome after 6 months of treatment and prednisolone was scaled down to
a maintenance dose of 0.5mg/kg/day. Fibrinogen levels went back to
normal (2.14g/L) after seventeen months of treatment, and the tumor
shrinked significantly. Conclusion. This case report shows that a
combination of prednisolone and propranolol has been effective for KMP
and kaposiform hemangioendothelioma. Timely recognition and treatment of
Kasabach-Merritt phenomenon's are essenti%
\end{abstract}%



\sloppy




\selectlanguage{english}
\FloatBarrier
\end{document}

