References
Ahmadian, M., Suh, J.M., Hah, N., Liddle, C., Atkins, A.R., Downes, M., & Evans, R.M. (2013). PPAR gamma signaling and metabolism: the good, the bad and the future. NATURE MEDICINE . 19(5), 557-566. https://doi.org/10.1038/nm.3159.
Amy Fleischman, M.M., Steven E. Shoelson, M.P., Raquel Bernier, B., & Allison B. Goldfine, M. (2008). Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults. DIABETES CARE . https://doi.org/10.2337/dc07.
Arner, P., & Kulyte, A. (2015). MicroRNA regulatory networks in human adipose tissue and obesity. NATURE REVIEWS ENDOCRINOLOGY . 11(5), 276-288. https://doi.org/10.1038/nrendo.2015.25.
Bellary, S., Kyrou, I., Brown, J.E., & Bailey, C.J. (2021). Type 2 diabetes mellitus in older adults: clinical considerations and management.NATURE REVIEWS ENDOCRINOLOGY . 17(9), 534-548. https://doi.org/10.1038/s41574-021-00512-2.
Bosma, M., Kersten, S., Hesselink, M., & Schrauwen, P. (2012). Re-evaluating lipotoxic triggers in skeletal muscle: Relating intramyocellular lipid metabolism to insulin sensitivity. PROGRESS IN LIPID RESEARCH . 51(1), 36-49. https://doi.org/10.1016/j.plipres.2011.11.003.
Cani, P.D., Neyrinck, A.M., Fava, F., Knauf, C., Burcelin, R.G., & Tuohy, K.M., et al. (2007). Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. DIABETOLOGIA . 50(11), 2374-2383. https://doi.org/10.1007/s00125-007-0791-0.
Chait, A., & den Hartigh, L.J. (2020). Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE . 7, 22. https://doi.org/10.3389/fcvm.2020.00022.
Chen, C., Huang, Q., Li, C., & Fu, X. (2017). Hypoglycemic effects of a Fructus Mori polysaccharide in vitro and in vivo. FOOD & FUNCTION . 8(7), 2523-2535. https://doi.org/10.1039/c7fo00417f.
Chen, C., Kuo, C., Leu, Y., & Wang, S. (2021). Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. PHARMACOLOGICAL RESEARCH . 164, 105291. https://doi.org/10.1016/j.phrs.2020.105291.
Chen, L., Chen, R., Wang, H., & Liang, F.X. (2015). Mechanisms Linking Inflammation to Insulin Resistance. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY . 2015. https://doi.org/10.1155/2015/508409.
Chen, S.S., Xu, M.L., Zhou, M., He, Y.X., Li, Y.C., & Lang, H., et al. (2022). Hibiscus manihot L improves obesity in mice induced by a high-fat diet. JOURNAL OF FUNCTIONAL FOODS . 89. https://doi.org/10.1016/j.jff.2022.104953.
Chen, Y.N., Qian, Q.A., & Yu, J.A. (2019). Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the I kappa B-alpha/NF-kappa B pathway and NLRP3 inflammasome.BIOMEDICINE & PHARMACOTHERAPY . 115. https://doi.org/10.1016/j.biopha.2019.108868.
Chondronikola, M., Volpi, E., Borsheim, E., Porter, C., Annamalai, P., & Enerback, S., et al. (2014). Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans. DIABETES . 63(12), 4089-4099. https://doi.org/10.2337/db14-0746.
Cote, C.D., Rasmussen, B.A., Duca, F.A., Zadeh-Tahmasebi, M., Baur, J.A., & Daljeet, M., et al. (2015). Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.NATURE MEDICINE . 21(5), 498-505. https://doi.org/10.1038/nm.3821.
Cote, C.D., Rasmussen, B.A., Duca, F.A., Zadeh-Tahmasebi, M., Baur, J.A., & Daljeet, M., et al. (2015). Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.NATURE MEDICINE . 21(5), 284-498. https://doi.org/10.1038/nm.3821.
Cucinotta, D., Nicolucci, A., Giandalia, A., Lucisano, G., Manicardi, V., & Mannino, D., et al. (2021). Temporal trends in intensification of glucose-lowering therapy for type 2 diabetes in Italy: Data from the AMD Annals initiative and their impact on clinical inertia. DIABETES RESEARCH AND CLINICAL PRACTICE . 181, 109096. https://doi.org/10.1016/j.diabres.2021.109096.
Day, E.A., Ford, R.J., & Steinberg, G.R. (2017). AMPK as a Therapeutic Target for Treating Metabolic Diseases. TRENDS IN ENDOCRINOLOGY AND METABOLISM . 28(8), 545-560. https://doi.org/10.1016/j.tem.2017.05.004.
den Besten, G., Bleeker, A., Gerding, A., van Eunen, K., Havinga, R., & van Dijk, T.H., et al. (2015). Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPAR-Dependent Switch from Lipogenesis to Fat Oxidation. DIABETES . 64(7), 2398-2408. https://doi.org/10.2337/db14-1213.
Ding, L., Jin, D.Z., & Chen, X.L. (2010). Luteolin enhances insulin sensitivity via activation of PPAR gamma transcriptional activity in adipocytes. JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 21(10), 941-947. https://doi.org/10.1016/j.jnutbio.2009.07.009.
Ding, X.Q., Gu, T.T., Wang, W., Song, L., Chen, T.Y., & Xue, Q.C., et al. (2015). Curcumin protects against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206. MOLECULAR NUTRITION & FOOD RESEARCH . 59(12), 2355-2370. https://doi.org/10.1002/mnfr.201500370.
Donath, M.Y., Dinarello, C.A., & Mandrup-Poulsen, T. (2019). Targeting innate immune mediators in type 1 and type 2 diabetes. NATURE REVIEWS IMMUNOLOGY . 19(12), 734-746. https://doi.org/10.1038/s41577-019-0213-9.
Duan, Y.N., Ge, X., Jiang, H.W., Zhang, H.J., Zhao, Y., & Li, J.L., et al. (2020). Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes. FRONTIERS IN ENDOCRINOLOGY . 11. https://doi.org/10.3389/fendo.2020.592818.
Faheem, A., Rehman, K., Jabeen, K., & Akash, M. (2020). Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY . 80. https://doi.org/10.1016/j.etap.2020.103506.
Fan, R., You, M., Toney, A.M., Kim, J., Giraud, D., & Xian, Y., et al. (2020). Red Raspberry Polyphenols Attenuate High‐Fat Diet–Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications. MOLECULAR NUTRITION & FOOD RESEARCH . 64(15), 1900995. https://doi.org/10.1002/mnfr.201900995.
Fang, S.S., Dong, L., Liu, L., Guo, J.C., Zhao, L.H., & Zhang, J.Y., et al. (2021). HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine. NUCLEIC ACIDS RESEARCH . 49(D1), D1197-D1206. https://doi.org/10.1093/nar/gkaa1063.
Feng, Y., Huang, S.L., Dou, W., Zhang, S., Chen, J.H., & Shen, Y., et al. (2010). Emodin, a natural product, selectively inhibits 11 beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. BRITISH JOURNAL OF PHARMACOLOGY . 161(1), 113-126. https://doi.org/10.1111/j.1476-5381.2010.00826.x.
Gao, L.Y., Tang, H., Zeng, Q.F., Tang, T., Chen, M., & Pu, P. (2020). The anti-insulin resistance effect of scutellarin may be related to antioxidant stress and AMPK alpha activation in diabetic mice.OBESITY RESEARCH & CLINICAL PRACTICE . 14(4), 368-374. https://doi.org/10.1016/j.orcp.2020.06.005.
Gijs Den Besten, A.B.A.G., Rick Havinga, T.H.V.D., & Albert K. Groen, D.R.A.B. (2015). Short-Chain Fatty Acids Protect Against High-Fat Diet – Induced Obesity via a PPARγ-Dependent Switch from Lipogenesis to Fat Oxidation. DIABETES . https://doi.org/10.2337/db14-1213.
Gomes, A.P., Duarte, F.V., Nunes, P., Hubbard, B.P., Teodoro, J.S., & Varela, A.T., et al. (2012). Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE . 1822(2), 185-195. https://doi.org/10.1016/j.bbadis.2011.10.008.
Gong, P., Xiao, X.Y., Wang, S., Shi, F.X., Liu, N., & Chen, X.F., et al. (2021). Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway. JOURNAL OF ETHNOPHARMACOLOGY . 281. https://doi.org/10.1016/j.jep.2021.114558.
Gonzalez-Rodriguez, A., Santamaria, B., Mas-Gutierrez, J.A., Rada, P., Fernandez-Millan, E., & Pardo, V., et al. (2015). Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.MOLECULAR NUTRITION & FOOD RESEARCH . 59(8), 1431-1442. https://doi.org/10.1002/mnfr.201400933.
Gordon, D.M., Neifer, K.L., Hamoud, A., Hawk, C.F., Nestor-Kalinoski, A.L., & Miruzzi, S.A., et al. (2020). Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α. JOURNAL OF BIOLOGICAL CHEMISTRY . 295(29), 9804-9822. https://doi.org/10.1074/jbc.RA120.013700.
Gustafson, B., Hedjazifar, S., Gogg, S., Hammarstedt, A., & Smith, U. (2015). Insulin resistance and impaired adipogenesis. TRENDS IN ENDOCRINOLOGY AND METABOLISM . 26(4), 193-200. https://doi.org/10.1016/j.tem.2015.01.006.
Hardie, D.G. (2013). AMPK: A Target for Drugs and Natural Products with Effects on Both Diabetes and Cancer. DIABETES . 62(7), 2164-2172. https://doi.org/10.2337/db13-0368.
He, L.Y., Yang, F.Q., Tang, P., Gao, T.H., Yang, C.X., & Tan, L., et al. (2022). Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus.BIOMEDICINE & PHARMACOTHERAPY . 151. https://doi.org/10.1016/j.biopha.2022.113091.
Honda, H., Nagai, Y., Matsunaga, T., Okamoto, N., Watanabe, Y., & Tsuneyama, K., et al. (2014). Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.JOURNAL OF LEUKOCYTE BIOLOGY . 96(6), 1087-1100. https://doi.org/10.1189/jlb.3A0114-005RR.
Hoxhaj, G., & Manning, B.D. (2020). The PI3K-AKT network at the interface of oncogenic signaling and cancer metabolism. NATURE REVIEWS CANCER . 20(2), 74-88. https://doi.org/10.1038/s41568-019-0216-7.
Hui, X.Y., Zhang, M.L., Gu, P., Li, K., Gao, Y., & Wu, D.H., et al. (2017). Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. EMBO REPORTS . 18(4), 645-657. https://doi.org/10.15252/embr.201643184.
Islam, T., Koboziev, I., Albracht-Schulte, K., Mistretta, B., Scoggin, S., & Yosofvand, M., et al. (2021). Curcumin Reduces Adipose Tissue Inflammation and Alters Gut Microbiota in Diet-Induced Obese Male Mice.MOLECULAR NUTRITION & FOOD RESEARCH . 65(22). https://doi.org/10.1002/mnfr.202100274.
Jayaraman, S., Devarajan, N., Rajagopal, P., Babu, S., Ganesan, S.K., & Veeraraghavan, V.P., et al. (2021). β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats. MOLECULES . 26(7), 2101. https://doi.org/10.3390/molecules26072101.
Ji, C.B., & Guo, X.R. (2019). The clinical potential of circulating microRNAs in obesity. NATURE REVIEWS ENDOCRINOLOGY . 15(12), 731-743. https://doi.org/10.1038/s41574-019-0260-0.
Jin, X., Amitani, K., Zamami, Y., Takatori, S., Hobara, N., & Kawamura, N., et al. (2010). Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats. JOURNAL OF ETHNOPHARMACOLOGY . 128(3), 672-678. https://doi.org/10.1016/j.jep.2010.02.019.
Johnson, A., & Olefsky, J.M. (2013). The Origins and Drivers of Insulin Resistance. CELL . 152(4), 673-684. https://doi.org/10.1016/j.cell.2013.01.041.
Johnson, A.R., Milner, J.J., & Makowski, L. (2012). The inflammation highway: metabolism accelerates inflammatory traffic in obesity.IMMUNOLOGICAL REVIEWS . 249, 218-238. https://doi.org/10.1111/j.1600-065X.2012.01151.x.
Jun, H.J., Lee, J.H., Kim, J., Jia, Y., Kim, K.H., & Hwang, K.Y., et al. (2014). Linalool is a PPAR alpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome.JOURNAL OF LIPID RESEARCH . 55(6), 1098-1110. https://doi.org/10.1194/jlr.M045807.
Jung, T.W., Kim, H., Park, S.Y., Cho, W., Oh, H., & Lee, H.J., et al. (2022). Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION . 45(11), 2181-2191. https://doi.org/10.1007/s40618-022-01866-8.
Kahn, B.B., Alquier, T., Carling, D., & Hardie, D.G. (2005). AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. CELL METABOLISM . 1(1), 15-25. https://doi.org/10.1016/j.cmet.2004.12.003.
Kang, J.H., Tsuyoshi, G., Han, I.S., Kawada, T., Kim, Y.M., & Yu, R. (2010). Dietary Capsaicin Reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice Fed a High-fat Diet. OBESITY . 18(4), 780-787. https://doi.org/10.1038/oby.2009.301.
Karkeni, E., Bonnet, L., Marcotorchino, J., Tourniaire, F., Astier, J., Ye, J.P., & Landrier, J.F. (2018). Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: A new mechanism for the regulation of inflammation by vitamin D. EPIGENETICS . 13(2), 156-162. https://doi.org/10.1080/15592294.2016.1276681.
Keuper, M., & Jastroch, M. (2021). The good and the BAT of metabolic sex differences in thermogenic human adipose tissue. MOLECULAR AND CELLULAR ENDOCRINOLOGY . 533. https://doi.org/10.1016/j.mce.2021.111337.
Kim, D.H., Kim, S.M., Lee, B., Lee, E.K., Chung, K.W., & Moon, K.M., et al. (2017). Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome. JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 45, 104-114. https://doi.org/10.1016/j.jnutbio.2017.04.014
Kim, O.Y., Chung, J.Y., & Song, J. (2019). Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity. PHARMACOLOGICAL RESEARCH . 148. https://doi.org/10.1016/j.phrs.2019.104411.
Kim, Y., Wang, W., Okla, M., Kang, I., Moreau, R., & Chung, S. (2016). Suppression of NLRP3 inflammasome by gamma-tocotrienol ameliorates type 2 diabetes. JOURNAL OF LIPID RESEARCH . 57(1), 66-76. https://doi.org/10.1194/jlr.M062828.
Kim, Y.J., Choi, J.Y., Ryu, R., Lee, J., Cho, S.J., & Kwon, E.Y., et al. (2016). Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue. NUTRIENTS . 8(9). https://doi.org/10.3390/nu8090532.
Kojta, I., Chacinska, M., & Blachnio-Zabielska, A. (2020). Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance.NUTRIENTS . 12(5). https://doi.org/10.3390/nu12051305.
Kong, P., Zhang, L., Guo, Y., Lu, Y., & Lin, D. (2014). Phillyrin, a natural lignan, attenuates tumor necrosis factor alpha-mediated insulin resistance and lipolytic acceleration in 3T3-L1 adipocytes. PLANTA MEDICA . 80(11), 880-886. https://doi.org/10.1055/s-0034-1368614.
Kunnumakkara, A.B., Bordoloi, D., Padmavathi, G., Monisha, J., Roy, N.K., Prasad, S., & Aggarwal, B.B. (2017). Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. BRITISH JOURNAL OF PHARMACOLOGY . 174(11), 1325-1348. https://doi.org/10.1111/bph.13621.
Kwon, E.Y., Jung, U.J., Park, T., Yun, J.W., & Choi, M.S. (2015). Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity. DIABETES . 64(5), 1658-1669. https://doi.org/10.2337/db14-0631.
Kwon, E.Y., & Choi, M.S. (2018). Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice. NUTRIENTS . 10(10). https://doi.org/10.3390/nu10101415.
Law, S.K., Wang, Y., Lu, X., Au, D.C.T., Chow, W.Y.L., Leung, A.W.N., & Xu, C. (2022). Chinese medicinal herbs as potential prodrugs for obesity.FRONTIERS IN PHARMACOLOGY . 13. https://doi.org/10.3389/fphar.2022.1016004.
Lee, A., Gu, H., Gwon, M.H., & Yun, J.M. (2021). Hesperetin suppresses LPS/high glucose-induced inflammatory responses via TLR/MyD88/NF-kappa B signaling pathways in THP-1 cells. NUTRITION RESEARCH AND PRACTICE . 15(5), 591-603. https://doi.org/10.4162/nrp.2021.15.5.591.
Lee, C.G., Rhee, D.K., Kim, B.O., Um, S.H., & Pyo, S. (2019). Allicin induces beige-like adipocytes via KLF15 signal cascade. JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 64, 13-24. https://doi.org/10.1016/j.jnutbio.2018.09.014.
Lee, H.M., Kim, J.J., Kim, H.J., Shong, M., Ku, B.J., & Jo, E.K. (2013). Upregulated NLRP3 Inflammasome Activation in Patients with Type 2 Diabetes. DIABETES . 62(1), 194-204. https://doi.org/10.2337/db12-0420.
Lee, S.H., Park, S.Y., & Choi, C.S. (2022). Insulin Resistance: From Mechanisms to Therapeutic Strategies. DIABETES & METABOLISM JOURNAL . 46(1), 15-37. https://doi.org/10.4093/dmj.2021.0280.
Li Qiang, L.W.N.K., & Yingming Zhao, W.G.S.R. (2012). Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPARγ.CELL . 150(3), 620-632. https://doi.org/10.1016/j.cell.2012.06.027.
Li, G.L., Xie, C., Lu, S.Y., Nichols, R.G., Tian, Y., & Li, L.C., et al. (2017). Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (vol 26, pg 672, 2017).CELL METABOLISM . 26(5), 801. https://doi.org/10.1016/j.cmet.2017.10.007.
Li, J., Zhang, Y.J., Zeng, X., Cheng, Y.H., Tang, L., Hong, D., & Yang, X.L. (2022). Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 99. https://doi.org/10.1016/j.jnutbio.2021.108862.
Li, P., Ding, L.Q., Cao, S.J., Feng, X.C., Zhang, Q., & Chen, Y.W., et al. (2020). Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells. JOURNAL OF ETHNOPHARMACOLOGY . 259. https://doi.org/10.1016/j.jep.2020.113015.
Li, R., Xia, Y.J., Gao, Z.Z., Song, Y., Guo, Z.W., & Yang, Y. (2021). Transcriptome analysis to reveal the mechanism of the effect of Echinops latifolius polysaccharide B on palmitate-induced insulin-resistant.BIOMEDICINE & PHARMACOTHERAPY . 143. https://doi.org/10.1016/j.biopha.2021.112203.
Li, S., You, J.M., Wang, Z.R., Liu, Y., Wang, B., Du, M., & Zou, T.D. (2021). Curcumin alleviates high-fat diet-induced hepatic steatosis and obesity in association with modulation of gut microbiota in mice.FOOD RESEARCH INTERNATIONAL . 143. https://doi.org/10.1016/j.foodres.2021.110270.
Li, W., Song, Y., Cao, Y.N., Zhang, L.L., Zhao, G., Wu, D.T., & Zou, L. (2022). Total saponins from quinoa bran alleviate high-fat diet-induced obesity and systemic inflammation via regulation of gut microbiota in rats. FOOD SCIENCE & NUTRITION . https://doi.org/10.1002/fsn3.2984.
Li, Y., Chen, X., Chen, Y., Yu, D., Jiang, R., & Kou, X., et al. (2022). Berberine Improves TNF-α-Induced Hepatic Insulin Resistance by Targeting MEKK1/MEK Pathway. INFLAMMATION . 45(5), 2016-2026. https://doi.org/10.1007/s10753-022-01671-8.
Li, Y.C., Wang, B.Y., Shen, J.D., Bai, M., & Xu, E.P. (2020). Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1 alpha pathway in mice. PHARMACEUTICAL BIOLOGY . 58(1), 385-392. https://doi.org/10.1080/13880209.2020.1756349.
Lin, S.C., & Hardie, D.G. (2018). AMPK: Sensing Glucose as well as Cellular Energy Status. CELL METABOLISM . 27(2), 299-313. https://doi.org/10.1016/j.cmet.2017.10.009.
Lindegaard, B., Matthews, V.B., Brandt, C., Hojman, P., Allen, T.L., & Estevez, E., et al. (2013). Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice. DIABETES . 62(9), 3064-3074. https://doi.org/10.2337/db12-1095.
Liong, S., & Lappas, M. (2015). Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY . 71(4), 703-717. https://doi.org/10.1007/s13105-015-0435-7.
Liu, X., Zhang, J.J., Li, Y.M., Sun, L.Y., Xiao, Y., Gao, W.G., & Zhang, Z.S. (2019). Mogroside derivatives exert hypoglycemics effects by decreasing blood glucose level in HepG2 cells and alleviates insulin resistance in T2DM rats. JOURNAL OF FUNCTIONAL FOODS . 63. https://doi.org/10.1016/j.jff.2019.103566.
Luo, G., Huang, B.Q., Qiu, X., Xiao, L., Wang, N., & Gao, Q., et al. (2017). Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD (+)/NADH ratio. MOLECULAR NUTRITION & FOOD RESEARCH . 61(11). https://doi.org/10.1002/mnfr.201700087.
Ma, P., Li, X., Wang, Y., Lang, D., Liu, L., & Yi, Y., et al. (2022). Natural bioactive constituents from herbs and nutraceuticals promote browning of white adipose tissue. PHARMACOLOGICAL RESEARCH . 178, 106175. https://doi.org/10.1016/j.phrs.2022.106175.
Mahjabeen, W., Khan, D.A., Mirza, S.A., & Pervez, M.A. (2021). Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial. PHYTOTHERAPY RESEARCH . 35(7), 3968-3976. https://doi.org/10.1002/ptr.7113.
Mazibuko-Mbeje, S.E., Dludla, P.V., Roux, C., Johnson, R., Ghoor, S., & Joubert, E., et al. (2019). Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES . 20(3). https://doi.org/10.3390/ijms20030633.
Medina-Vera, D., Navarro, J.A., Tovar, R., Rosell-Valle, C., Gutierrez-Adan, A., & Ledesma, J.C., et al. (2021). Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol. NUTRIENTS . 13(7). https://doi.org/10.3390/nu13072268.
Modi, S., Yaluri, N., Kokkola, T., & Laakso, M. (2017). Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells. SCIENTIFIC REPORTS . 7(1). https://doi.org/10.1038/s41598-017-17840-x.
Montaigne, D., Butruille, L., & Staels, B. (2021). PPAR control of metabolism and cardiovascular functions. NATURE REVIEWS CARDIOLOGY . 18(12), 809-823. https://doi.org/10.1038/s41569-021-00569-6.
Mu, J., Xin, G., Zhang, B., Wang, Y., Ning, C., & Meng, X. (2020). Beneficial effects of Aronia Melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats. Journal of FOOD SCIENCE . 85(4), 1307-1318. https://doi.org/10.1111/1750-3841.15109.
Murugesan, N., Woodard, K., Ramaraju, R., Greenway, F.L., Coulter, A.A., & Rebello, C.J. (2020). Naringenin Increases Insulin Sensitivity and Metabolic Rate: A Case Study. JOURNAL OF MEDICINAL FOOD . 23(3), 343-348. https://doi.org/10.1089/jmf.2019.0216.
Najjar, S.M., Caprio, S., & Gastaldelli, A. (2023). Insulin Clearance in Health and Disease. ANNUAL REVIEW OF PHYSIOLOGY . 85, 363-381. https://doi.org/10.1146/annurev-physiol-031622-043133.
Ni, J.Y., Liu, Z.H., Jiang, M.M., Li, L., Deng, J., & Wang, X.D., et al. (2022). Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.JOURNAL OF GINSENG RESEARCH . 46(2), 235-247. https://doi.org/10.1016/j.jgr.2021.06.001.
Nicholas, L.M., Morrison, J.L., Rattanatray, L., Zhang, S., Ozanne, S.E., & McMillen, I.C. (2016). The early origins of obesity and insulin resistance: timing, programming and mechanisms. INTERNATIONAL JOURNAL OF OBESITY . 40(2), 229-238. https://doi.org/10.1038/ijo.2015.178
Ohno, M., Shibata, C., Kishikawa, T., Yoshikawa, T., Takata, A., & Kojima, K., et al. (2013). The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.SCIENTIFIC REPORTS . 3. https://doi.org/10.1038/srep02553.
Osborn, O., & Olefsky, J.M. (2012). The cellular and signaling networks linking the immune system and metabolism in disease. NATURE MEDICINE . 18(3), 363-374. https://doi.org/10.1038/nm.2627.
Otton, R., Bolin, A.P., Ferreira, L.T., Marinovic, M.P., Rocha, A., & Mori, M.A. (2018). Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 57, 170-179. https://doi.org/10.1016/j.jnutbio.2018.03.024.
Palomares, B., Ruiz-Pino, F., Garrido-Rodriguez, M., Prados, M.E., Sanchez-Garrido, M.A., & Velasco, I., et al. (2020). Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity. BIOCHEMICAL PHARMACOLOGY . 171. https://doi.org/10.1016/j.bcp.2019.113693.
Perreault, L., Skyler, J.S., & Rosenstock, J. (2021). Novel therapies with precision mechanisms for type 2 diabetes mellitus. NATURE REVIEWS ENDOCRINOLOGY . 17(6), 364-377. https://doi.org/10.1038/s41574-021-00489-y.
Petersen, M.C., & Shulman, G.I. (2017). Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance. TRENDS IN PHARMACOLOGICAL SCIENCES . 38(7), 649-665. https://doi.org/10.1016/j.tips.2017.04.004.
Pyun, D., Kim, T.J., Park, S.Y., Lee, H.J., Abd El-Aty, A.M., Jeong, J.H., & Jung, T.W. (2021). Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. MOLECULAR AND CELLULAR ENDOCRINOLOGY . 538. https://doi.org/10.1016/j.mce.2021.111464.
Qiang, L., Wang, L.H., Kon, N., Zhao, W.H., Lee, S., & Zhang, Y.Y., et al. (2012). Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Ppar gamma. CELL . 150(3), 620-632. https://doi.org/10.1016/j.cell.2012.06.027.
Qiao, Y., Sun, J., Xia, S.F., Tang, X., Shi, Y.H., & Le, G.W. (2014). Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity. FOOD & FUNCTION . 5(6), 1241-1249. https://doi.org/10.1039/c3fo60630a.
Qiao, Z.J., Du, X.X., Zhuang, W.Y., Yang, S., Li, H., & Sun, J.H., et al. (2020). Schisandra Chinensis Acidic Polysaccharide Improves the Insulin Resistance in Type 2 Diabetic Rats by Inhibiting Inflammation.JOURNAL OF MEDICINAL FOOD . 23(4), 358-366. https://doi.org/10.1089/jmf.2019.4469.
Reilly, S.M., Ahmadian, M., Zamarron, B.F., Chang, L., Uhm, M., & Poirier, B., et al. (2015). A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. NATURE COMMUNICATIONS . 6. https://doi.org/10.1038/ncomms7047.
Rogacka, D., Audzeyenka, I., Rychlowski, M., Rachubik, P., Szrejder, M., Angielski, S., & Piwkowska, A. (2018). Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE . 1864(1), 115-125. https://doi.org/10.1016/j.bbadis.2017.10.014.
Rohm, T.V., Meier, D.T., Olefsky, J.M., & Donath, M.Y. (2022). Inflammation in obesity, diabetes, and related disorders. IMMUNITY . 55(1), 31-55. https://doi.org/10.1016/j.immuni.2021.12.013.
Rosengren, A., & Dikaiou, P. (2023). Cardiovascular outcomes in type 1 and type 2 diabetes. DIABETOLOGIA . 66(3), 425-437. https://doi.org/10.1007/s00125-022-05857-5.
Saad, M., Santos, A., & Prada, P.O. (2016). Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. PHYSIOLOGY . 31(4), 283-293. https://doi.org/10.1152/physiol.00041.2015.
Sakamoto, Y., Naka, A., Ohara, N., Kondo, K., & Iida, K. (2014). Daidzein regulates proinflammatory adipokines thereby improving obesity- related inflammation through PPAR. MOLECULAR NUTRITION & FOOD RESEARCH . 58(4), 718-726. https://doi.org/10.1002/mnfr.201300482.
Samuel, V.T., & Shulman, G.I. (2012). Mechanisms for Insulin Resistance: Common Threads and Missing Links. CELL . 148(5), 852-871. https://doi.org/10.1016/j.cell.2012.02.017.
Samuel, V.T., & Shulman, G.I. (2016). The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. JOURNAL OF CLINICAL INVESTIGATION . 126(1), 12-22. https://doi.org/10.1172/JCI77812.
Sharma, B.R., Kim, H.J., & Rhyu, D.Y. (2015). Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytes.JOURNAL OF TRANSLATIONAL MEDICINE . 13. https://doi.org/10.1186/s12967-015-0412-5.
Shen, S., Liao, Q., Zhang, T., Pan, R., & Lin, L. (2019). Myricanol modulates skeletal muscle–adipose tissue crosstalk to alleviate high‐fat diet‐induced obesity and insulin resistance. BRITISH JOURNAL OF PHARMACOLOGY . 176(20), 3983-4001. https://doi.org/10.1111/bph.14802.
Shu, L.Y., Zhao, H., Huang, W.L., Hou, G.S., Song, G.Y., & Ma, H.J. (2020). Resveratrol Upregulates mmu-miR-363-3p via the PI3K-Akt Pathway to Improve Insulin Resistance Induced by a High-Fat Diet in Mice.DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY . 13, 391-403. https://doi.org/10.2147/DMSO.S240956.
Snoke, D.B., Nishikawa, Y., Cole, R.M., Ni, A., Angelotti, A., Vodovotz, Y., & Belury, M.A. (2021). Dietary Naringenin Preserves Insulin Sensitivity and Grip Strength and Attenuates Inflammation but Accelerates Weight Loss in a Mouse Model of Cancer Cachexia. MOLECULAR NUTRITION & FOOD RESEARCH . 65(22), 2100268. https://doi.org/10.1002/mnfr.202100268.
Song, H.Z., Shen, X.C., Deng, R., Zhang, Y., & Zheng, X.D. (2021). Dietary anthocyanin-rich extract of acai protects from diet-induced obesity, liver steatosis, and insulin resistance with modulation of gut microbiota in mice. NUTRITION . 86. https://doi.org/10.1016/j.nut.2021.111176.
Stanford, K.I., Middelbeek, R.J.W., Townsend, K.L., An, D., Nygaard, E.B., & Hitchcox, K.M., et al. (2013). Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. JOURNAL OF CLINICAL INVESTIGATION . 123(1), 215-223. https://doi.org/10.1172/JCI62308.
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012). Inflammasomes in health and disease. NATURE . 481(7381), 278-286. https://doi.org/10.1038/nature10759.
Su, M., Hu, R., Tang, T., Tang, W.W., & Huang, C.X. (2023). Review of the correlation between Chinese medicine and intestinal microbiota on the efficacy of diabetes mellitus. FRONTIERS IN ENDOCRINOLOGY . 13. https://doi.org/10.3389/fendo.2022.1085092.
Su, X., Wang, W., Fang, C., Ni, C., Zhou, J., & Wang, X., et al. (2021). Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitochondrial Function Via SIRT1 Signaling. ANTIOXIDANTS & REDOX SIGNALING . 34(2), 99-117. https://doi.org/10.1089/ars.2019.7908.
Sun, C., Zhang, F., Ge, X.J., Yan, T.T., Chen, X.M., Shi, X.L., & Zhai, Q.W. (2007). SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. CELL METABOLISM . 6(4), 307-319. https://doi.org/10.1016/j.cmet.2007.08.014.
Sun, J., Tang, Y.H., Yu, X., Xu, Y.Y., Liu, P.Y., & Xiao, L., et al. (2016). Flaxseed lignans alleviate high fat diet-induced hepatic steatosis and insulin resistance in mice: Potential involvement of AMP-activated protein kinase. JOURNAL OF FUNCTIONAL FOODS . 24, 482-491. https://doi.org/10.1016/j.jff.2016.04.032.
Sylow, L., Tokarz, V.L., Richter, E.A., & Klip, A. (2021). The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia.CELL METABOLISM . 33(4), 758-780. https://doi.org/10.1016/j.cmet.2021.03.020.
Szkudelski, T., & Szkudelska, K. (2015). Resveratrol and diabetes: from animal to human studies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE . 1852(6), 1145-1154. https://doi.org/10.1016/j.bbadis.2014.10.013.
Tan, J.L., Huang, C., Luo, Q.H., Liu, W.T., Cheng, D.J., & Li, Y.F., et al. (2019). Soy Isoflavones Ameliorate Fatty Acid Metabolism of Visceral Adipose Tissue by Increasing the AMPK Activity in Male Rats with Diet-Induced Obesity (DIO). MOLECULES . 24(15). https://doi.org/10.3390/molecules24152809.
Tang, S., Le-Tien, H., Goldstein, B.J., Shin, P., Lai, R., & Fantus, I.G. (2001). Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes.DIABETES . 50(1), 83-90. https://doi.org/10.2337/diabetes.50.1.83.
Tong, T.T., Ren, N., Soomi, P., Wu, J.F., Guo, N., & Kang, H., et al. (2018). Theaflavins Improve Insulin Sensitivity through Regulating Mitochondrial Biosynthesis in Palmitic Acid-Induced HepG2 Cells. MOLECULES . 23(12). https://doi.org/10.3390/molecules23123382.
Tsatsoulis, A., Mantzaris, M.D., Bellou, S., & Andrikoula, M. (2013). Insulin resistance: An adaptive mechanism becomes maladaptive in the current environment - An evolutionary perspective. METABOLISM-CLINICAL AND EXPERIMENTAL . 62(5), 622-633. https://doi.org/10.1016/j.metabol.2012.11.004.
Tsukumo, D.M., Carvalho, B.M., Carvalho, M.A., & Saad, M. (2015). Translational research into gut microbiota: new horizons on obesity treatment: updated 2014. ARCHIVES OF ENDOCRINOLOGY METABOLISM . 59(2), 154-160. https://doi.org/10.1590/2359-3997000000029.
Wan, X.Y., Xu, C.F., Lu, C., Zhu, H.T., Yu, C.H., & Li, Y.M. (2015). Uric Acid Regulates Hepatic Steatosis and Insulin Resistance Through the NLRP3 Inflammasome Dependent Mechanism. GASTROENTEROLOGY . 148(4), S1053.
Wang, K.P., Wang, H.X., Liu, Y.G., Shui, W.Z., Wang, J.F., & Cao, P., et al. (2018). Dendrobiurn officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism. JOURNAL OF FUNCTIONAL FOODS . 40, 261-271. https://doi.org/10.1016/j.jff.2017.11.004.
Wang, P., Caspi, L., Lam, C., Chari, M., Li, X.S., & Light, P.E., et al. (2008). Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. NATURE . 452(7190), 1012-1016. https://doi.org/10.1038/nature06852.
Wang, Z., Xue, L., Guo, C., Han, B., Pan, C., & Zhao, S., et al. (2012). Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-κB pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS . 417(4), 1280-1285. https://doi.org/10.1016/j.bbrc.2011.12.130.
Wang, Z.S., Lu, F.E., Xu, L.J., & Dong, H. (2010). Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. ACTA PHARMACOLOGICA SINICA . 31(5), 578-584. https://doi.org/10.1038/aps.2010.30.
Wei, Z.T., Weng, S.Y., Wang, L., & Mao, Z.J. (2018). Mechanism of Astragalus polysaccharides in attenuating insulin resistance in Rats with type 2 diabetes mellitus via the regulation of liver microRNA-203a-3p.MOLECULAR MEDICINE REPORTS . 17(1), 1617-1624. https://doi.org/10.3892/mmr.2017.8084.
Wu, S.J. (2015). Osthole Attenuates Inflammatory Responses and Regulates the Expression of Inflammatory Mediators in HepG2 Cells Grown in Differentiated Medium from 3T3-L1 Preadipocytes. JOURNAL OF MEDICINAL FOOD . 18(9), 972-979. https://doi.org/10.1089/jmf.2014.3314.
Xiao, D., Hu, Y.Y., Fu, Y.J., Wang, R., Zhang, H.Y., & Li, M.Q., et al. (2019). Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle. PHYTOMEDICINE . 59. https://doi.org/10.1016/j.phymed.2018.11.018.
Xie, D.D., Zhao, X.T., & Chen, M.W. (2021). Prevention and treatment strategies for type 2 diabetes based on regulating intestinal flora.BIOSCIENCE TRENDS . 15(5), 313-320. https://doi.org/10.5582/bst.2021.01275.
Xing, C., Xiang, D., & Li, C.Y. (2020). Effects of troxerutin on vascular inflammatory mediators and expression of microRNA-146a/NF-kappa B signaling pathway in aorta of healthy and diabetic rats. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY . 24(5), 395-402. https://doi.org/10.4196/kjpp.2020.24.5.395.
Xu, F., Zheng, X., Lin, B., Liang, H., Cai, M., & Cao, H., et al. (2016). Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice. OBESITY . 24(3), 634-642. https://doi.org/10.1002/oby.21393.
Xu, J., Cao, K., Feng, Z.H., & Liu, J.K. (2018). Benefits of the soluble and insoluble fractions of bitter gourd in mice fed a high-fat diet.JOURNAL OF FUNCTIONAL FOODS . 42, 216-223. https://doi.org/10.1016/j.jff.2018.01.002.
Xu, L.N., Yin, L.H., Jin, Y., Qi, Y., Han, X., & Xu, Y.W., et al. (2020). Effect and possible mechanisms of dioscin on ameliorating metabolic glycolipid metabolic disorder in type-2-diabetes. PHYTOMEDICINE . 67. https://doi.org/10.1016/j.phymed.2019.153139.
Xu, N., Zhang, L., Dong, J., Zhang, X., Chen, Y.G., Bao, B., & Liu, J. (2014). Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice.MOLECULAR NUTRITION & FOOD RESEARCH . 58(6), 1258-1268. https://doi.org/10.1002/mnfr.201300830.
Xu, X.M., Yi, H., Wu, J.S., Kuang, T.T., Zhang, J., & Li, Q., et al. (2021). Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. BIOMEDICINE & PHARMACOTHERAPY . 133. https://doi.org/10.1016/j.biopha.2020.110984.
Xu, X.S., Chen, Y.P., Song, J.N., Hou, F.J., Ma, X.L., Liu, B.L., & Huang, F. (2018). Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium. EUROPEAN JOURNAL OF NUTRITION . 57(4), 1563-1575. https://doi.org/10.1007/s00394-017-1441-z.
Xu, Y., Yu, T., Ma, G., Zheng, L., Jiang, X., & Yang, F., et al. (2021). Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES . 17(12), 3173-3187. https://doi.org/10.7150/ijbs.62556.
Xue, C.Y., Li, Y., Lv, H., Zhang, L., Bi, C.P., & Dong, N., et al. (2021). Oleanolic Acid Targets the Gut-Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY . 69(28), 7884-7897. https://doi.org/10.1021/acs.jafc.1c02257.
Yan, M.X., Ren, H.B., Kou, Y., Meng, M., & Li, Y.Q. (2012). Involvement of Nuclear Factor Kappa B in High-Fat Diet-Related Pancreatic Fibrosis in Rats. GUT AND LIVER . 6(3), 381-387. https://doi.org/10.5009/gnl.2012.6.3.381.
Yang, L., Lin, H.Q., Lin, W.T., & Xu, X.Y. (2020). Exercise Ameliorates Insulin Resistance of Type 2 Diabetes through Motivating Short-Chain Fatty Acid-Mediated Skeletal Muscle Cell Autophagy.BIOLOGY-BASEL . 9(8). https://doi.org/10.3390/biology9080203.
Yang, Y., Li, W., Li, Y., Wang, Q., Gao, L., & Zhao, J.J. (2014). Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT Signaling. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY . 2014. https://doi.org/10.1155/2014/145641.
Ying, W., Gao, H., Dos Reis, F., Bandyopadhyay, G., Ofrecio, J.M., & Luo, Z.L., et al. (2021). MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice.CELL METABOLISM . 33(4), 781. https://doi.org/10.1016/j.cmet.2020.12.019.
Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., & Seo, J.B., et al. (2017). Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. CELL . 171(2), 372. https://doi.org/10.1016/j.cell.2017.08.035.
Yoon, S.A., Kang, S.I., Shin, H.S., Kang, S.W., Kim, J.H., Ko, H.C., & Kim, S.J. (2013). p-Coumaric acid modulates glucose and lipid metabolism via AMP-activated protein kinase in L6 skeletal muscle cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS . 432(4), 553-557. https://doi.org/10.1016/j.bbrc.2013.02.067.
Yoshizaki, T., Schenk, S., Imamura, T., Babendure, J.L., Sonoda, N., & Bae, E.J., et al. (2010). SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM . 298(3), E419-E428. https://doi.org/10.1152/ajpendo.00417.2009.
You, B.Y., Dun, Y.S., Zhang, W.L., Jiang, L.J., Li, H., & Xie, M.R., et al. (2020). Anti-insulin resistance effects of salidroside through mitochondrial quality control. JOURNAL OF ENDOCRINOLOGY . 244(2), 383-393. https://doi.org/10.1530/JOE-19-0393.
Yu, X., Shen, N., Zhang, M.L., Pan, F.Y., Wang, C., & Jia, W.P., et al. (2011). Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO JOURNAL . 30(18), 3754-3765. https://doi.org/10.1038/emboj.2011.277.
Zhang, H.H., Ma, X.J., Wu, L.N., Zhao, Y.Y., Zhang, P.Y., & Zhang, Y.H., et al. (2015). SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells.EXPERIMENTAL BIOLOGY AND MEDICINE . 240(5), 557-565. https://doi.org/10.1177/1535370214557218.
Zhang, J.J., Cao, W., Zhao, H.A., Guo, S., Wang, Q., Cheng, N., & Bai, N.S. (2022). Protective Mechanism of Fagopyrum esculentum Moench. Bee Pollen EtOH Extract Against Type II Diabetes in a High-Fat Diet/Streptozocin-Induced C57BL/6J Mice. FRONTIERS IN NUTRITION . 9. https://doi.org/10.3389/fnut.2022.925351.
Zhang, M., Lv, X.Y., Li, J., Meng, Z.J., Wang, Q.J., & Chang, W.G., et al. (2012). Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. MOLECULAR AND CELLULAR ENDOCRINOLOGY . 363(1-2), 122-130. https://doi.org/10.1016/j.mce.2012.08.006.
Zhang, N., Liu, X.Y., Zhuang, L.L., Liu, X.M., Zhao, H.S., & Shan, Y.H., et al. (2020). Berberine decreases insulin resistance in a PCOS rats by improving GLUT4: Dual regulation of the PI3K/AKT and MAPK pathways.REGULATORY TOXICOLOGY AND PHARMACOLOGY . 110. https://doi.org/10.1016/j.yrtph.2019.104544.
Zhang, Q., Pan, Y., Wang, R., Kang, L., Xue, Q., Wang, X., & Kong, L. (2014). Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY . 25(4), 420-428. https://doi.org/10.1016/j.jnutbio.2013.11.014.
Zhang, S.H., Song, P.K., Chen, X.Y., Wang, Y., Gao, X.Y., Liang, L., & Zhao, J.X. (2022). Astragalus polysaccharide regulates brown adipocytes differentiation by miR-6911 targeting Prdm16. LIPIDS . 57(1), 45-55. https://doi.org/10.1002/lipd.12328.
Zhang, Y., Liu, X.F., Han, L.F., Gao, X.M., Liu, E.W., & Wang, T. (2013). Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways. FOOD CHEMISTRY . 141(3), 2896-2905. https://doi.org/10.1016/j.foodchem.2013.05.121.
Zhao, H., Zhang, Y.J., Shu, L.Y., Song, G.Y., & Ma, H.J. (2019). Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro. DRUG DESIGN DEVELOPMENT AND THERAPY . 13, 1473-1485. https://doi.org/10.2147/DDDT.S203833.
Zheng, X.K., Ke, Y.Y., Feng, A.Z., Yuan, P.P., Zhou, J., & Yu, Y., et al. (2016). The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells. MOLECULES . 21(5). https://doi.org/10.3390/molecules21050624.
Zhou, H., Feng, L.L., Xu, F., Sun, Y., Ma, Y.X., & Zhang, X., et al. (2017). Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement. BIOMEDICINE & PHARMACOTHERAPY . 89, 864-874. https://doi.org/10.1016/j.biopha.2017.03.003.
Zuo, J.C., Zhao, D.D., Yu, N., Fang, X., Mu, Q.Q., & Ma, Y., et al. (2017). Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY . 42(4), 1514-1525. https://doi.org/10.1159/000479268.