5 succinct key points:
  1. Animal phase trials using laboratory rats are widely used for otological studies as the middle and inner ear anatomy is nearly identical to humans.
  2. Henna leaf (Lawsomnia inermis) is widely available and has anti-fungal properties, but the safety profile has never been studied to be used as an anti-fungal ear drops solution.
  3. Henna extract can potentially be used as an alternative antifungal ear drops without any vestibulotoxic effect in an animal study.
  4. Henna extract is safe to be used even with tympanic membrane perforation without vestibulotoxic effect in an animal study.
  5. Henna extract has the potential to be commercialized as a new drug after thoroughly assessing the cochleovestibulotoxicity effect in human trials.
Keywords :
Animal; Endoscopic; Henna; Ototoxicity; Vestibulotoxicity