5 succinct key points:
- Animal phase trials using laboratory rats are widely used for
otological studies as the middle and inner ear anatomy is nearly
identical to humans.
- Henna leaf (Lawsomnia inermis) is widely available and has anti-fungal
properties, but the safety profile has never been studied to be used
as an anti-fungal ear drops solution.
- Henna extract can potentially be used as an alternative antifungal ear
drops without any vestibulotoxic effect in an animal study.
- Henna extract is safe to be used even with tympanic membrane
perforation without vestibulotoxic effect in an animal study.
- Henna extract has the potential to be commercialized as a new drug
after thoroughly assessing the cochleovestibulotoxicity effect in
human trials.
Keywords :
Animal; Endoscopic; Henna; Ototoxicity; Vestibulotoxicity