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\begin{document}

\title{Crosstalk of immune cells in chronic spontaneous urticaria}



\author[1]{cong peng}%
\author[2]{Xiang Chen}%
\author[1]{Bingjing Zhou}%
\author[2]{Jie Li}%
\author[1]{Runqiu Liu}%
\author[1]{Lei Zhu}%
\affil[1]{Xiangya Hospital Central South University}%
\affil[2]{Xiangya Hospital, Central South University}%


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  \date{May 22, 2024}


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\begin{abstract}
Chronic spontaneous urticaria (CSU) is defined as the recurrent episodes
of spontaneous wheals and/or angioedema for more than 6 weeks, and at
least twice a week. The core link in the pathogenesis of CSU is the
activation of mast cells and other immune cells caused by various
reasons. These activated immune cells release a series of inflammatory
active mediators such as histamine, arachidonic acid metabolites,
chemokines, etc., resulting in clinical features such as wheals and/or
edema. However, the specific mechanisms leading to the activation of
various immune cells have not been fully elucidated. Previous evidence
has shown that about 50\% of CSU patients have potential autoimmune
reactions. Here we review the functional implication of immune cells in
CSU focusing on the crosstalk between them and discuss whether their
crosstalk promotes the occurrence and development of the disease.%
\end{abstract}%



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