Sr. no. Chemicals used Route/Dose (mg/kg) of body weight of the animal Duration (weeks/days) Reference
1. Carbon tetrachloride Oral route, 2 ml/kg daily incorporated with corn oil at a ratio of 1:1 (v/v) for mice 10 weeks (27, 28)
Oral route, 4 ml/kg daily mixed with corn oil at a ratio of 1:1 (v/v) for rat 10 weeks
Intraperitoneal injection, 1 ml/kg mixed with corn oil at a ratio of 1:1 (v/v) for rat Thrice a week till four to six weeks
2.
Ethanol
Oral route,7.9 g/kg daily for mice, rat
6 weeks
(29, 30)
3. Thioacetamide Intraperitoneal injection, 200 mg/kg for mice, rat Thrice a week for 8 weeks (33, 34)
4.
Dimethyl nitrosamine
Intraperitoneal injection,10 mg/kg for mice, rat
Two times every week till four weeks
(36, 37)
5.
Lead nitrate
Oral route, 50 mg/kg for mice, rat
40 days
(39, 40)
Intraperitoneal injection, 5 mg/kg of dose for mice, rat
30 days
6.
D-galactosamine
Intraperitoneal injection, 500 mg/kg of dose for mice, rat
12 weeks
(43, 44)
Intraperitoneal injection, 800 mg/kg of dose for mice, rat
Single dose