1.3. Classification of Cirrhosis
Cirrhosis is classified based on morphology, etiology, and severity. Based on the morphological appearance of the liver in surgery, autopsy, or biopsy, it is divided into three categories i.e. micronodular, macronodular, and mixed (21). Etiologically cirrhosis is classified into the alcoholic, biliary, autoimmune, cardiac, postnecrotic, metabolic-associated fatty liver, and cirrhosis due to genetic deficiency (22). For determination of severity, Child-Pugh scoring is used considering five parameters i.e. bilirubin, serum albumin, international normalized ration (INR) (23), ascites, and hepatic encephalopathy (24).
IN-VIVO ANIMAL MODELS
Diverse animal models are used to study pathogenesis, mechanism of disease, and validation of drugs. They are a great source of knowledge to study the pathogenesis of hepatic cirrhosis and to check the safety and efficacy of hepatoprotective or antifibrotic drugs (25). There are different ways to induce liver cirrhosis in vivo animal models. These may be chemical-induced, drug-induced, food-induced, and surgical-induced hepatotoxicity.