1. |
Carbon tetrachloride |
Oral route, 2 ml/kg daily incorporated with
corn oil at a ratio of 1:1 (v/v) for mice |
10 weeks |
(27,
28) |
|
|
Oral route, 4 ml/kg daily mixed with corn oil at a ratio of 1:1
(v/v) for rat |
10 weeks |
|
|
|
Intraperitoneal injection, 1 ml/kg mixed with corn oil at a ratio of
1:1 (v/v) for rat |
Thrice a week till four to six weeks |
|
2.
|
Ethanol
|
Oral route,7.9 g/kg daily for mice, rat
|
6 weeks
|
(29, 30)
|
3. |
Thioacetamide |
Intraperitoneal injection, 200 mg/kg for mice, rat |
Thrice a week for 8 weeks |
(33, 34) |
4.
|
Dimethyl nitrosamine
|
Intraperitoneal injection,10 mg/kg for mice, rat
|
Two times every week till four weeks
|
(36, 37)
|
5.
|
Lead nitrate
|
Oral route, 50 mg/kg for mice, rat
|
40 days
|
(39, 40)
|
|
|
Intraperitoneal injection, 5 mg/kg of dose for mice, rat
|
30 days
|
|
6.
|
D-galactosamine
|
Intraperitoneal injection, 500 mg/kg of dose for mice, rat
|
12 weeks
|
(43, 44)
|
|
|
Intraperitoneal injection, 800 mg/kg of dose for mice, rat
|
Single dose
|
|