1.3. Classification of Cirrhosis
Cirrhosis is classified based on morphology, etiology, and severity.
Based on the morphological appearance of the liver in surgery, autopsy,
or biopsy, it is divided into three categories i.e. micronodular,
macronodular, and mixed (21). Etiologically cirrhosis is classified into
the alcoholic, biliary, autoimmune, cardiac, postnecrotic,
metabolic-associated fatty liver, and cirrhosis due to genetic
deficiency (22). For determination of severity, Child-Pugh scoring is
used considering five parameters i.e. bilirubin, serum albumin,
international normalized ration (INR) (23), ascites, and hepatic
encephalopathy (24).
IN-VIVO ANIMAL MODELS
Diverse animal models are used to study pathogenesis, mechanism of
disease, and validation of drugs. They are a great source of knowledge
to study the pathogenesis of hepatic cirrhosis and to check the safety
and efficacy of hepatoprotective or antifibrotic drugs (25). There are
different ways to induce liver cirrhosis in vivo animal models.
These may be chemical-induced, drug-induced, food-induced, and
surgical-induced hepatotoxicity.