1.1 Research Envisaged
Hepatotoxic drugs and alcohol intake are the leading causes of liver
injury throughout the world. Acute hepatitis is the cause of about 10%
cases of liver damage and another 50% result from drug induced hepatic
injury. 75% of total cases were documented as cased of liver
transplantation or death due to liver injury-induced idiosyncratic drug
reactions. Liver diseases have been placed on fifth number in the
leading cause of death across the world. There is an essential need for
the development of new drugs which are devoid of hepatotoxicity (8).In vivo animal models have been used for several decades for the
preclinical assessment of drugs. Various models of hepatic cirrhosis
have been established by using different methods such as chemicals,
drugs, diet, and surgery. There is a specific benefit of each model
based on short-term and long-term studies (9).