Major milestone discoveries High avidity interactions, and consequently, low affinity IgE antibodies can trigger cellular activation. Antibody affinity dictates the mechanism of mast cell inhibition, and low affinity IgG antibodies triggering the inhibitory FcγRIIb pathway can show a broader cross-reactivity pattern than previously thought. IgG subclasses plays only a minor role in inhibiting the allergic response; IgG1 as an equally dominant IgE-blocking antibody as IgG4. Repetitive display of allergens on VLPs packaged with TLR ligands appears an attractive way to broaden and increase induction and maintenance of specific antibodies; the basis of a novel vaccine against peanut allergy.