Limitations
There may be several limitations to these findings. Without a comparison group, it is difficult to prove which specific findings may predict development of interstitial lung disease or response to treatment. As a small case series conducted at a single center, the study is prone to bias, which can limit generalizability to broader populations. The study design did include clear objectives and well-defined inclusion and exclusion criteria for cases, which limited selection bias. We followed all patients to the conclusion of the designated time frame, improving validity.