Limitations
There may be several limitations to these findings. Without a comparison
group, it is difficult to prove which specific findings may predict
development of interstitial lung disease or response to treatment. As a
small case series conducted at a single center, the study is prone to
bias, which can limit generalizability to broader populations. The study
design did include clear objectives and well-defined inclusion and
exclusion criteria for cases, which limited selection bias. We followed
all patients to the conclusion of the designated
time frame, improving validity.