1. Acute onset of illness (minutes to several hours), with involvement
of the skin, mucosal tissue, or both (eg, generalized hives, pruritus or
flushing, swollen lips-tongue-uvula)
AND AT LEAST ONE OF THE FOLLOWING
a. Respiratory compromise (eg, dyspnea, wheeze-bronchospasm, stridor,
reduced peak expiratory flow(PEF), hypoxemia)
b. Reduced blood pressure(BP) or associated symptoms of end-organ
dysfunction (eg, hypotonia [collapse], syncope, incontinence)
2. Two or more of the following that occur rapidly after exposure to a
likely allergen for that patient (minutes to several hours):
a. Involvement of the skin-mucosal tissue (eg, generalized hives,
itch-flush, swollen lips-tongue-uvula)
b. Respiratory compromise (eg, dyspnea, wheeze-bronchospasm, stridor,
reduced PEF, hypoxemia)
c. Reduced BP or associated symptoms (eg, hypotonia[collapse],
syncope, incontinence)
d. Persistent gastrointestinal symptoms (eg, crampy abdominal pain,
vomiting)
3. Reduced BP after exposure to known allergen for that patient (minutes
to several hours):
a. Infants and children: low systolic BP (age specific) or greater than
30% decrease in systolic BP
b. Adults: systolic BP of less than 90 mm Hg or greater than 30%
decrease from that person,s baseline.
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