Results
No significant difference in neurometabolite concentrations was found between SZ and the healthy control groups. The MAP group had lower NAA+NAAG/Cr+PCr in left DLPFC (p<0.05) and left FWM (p<0.05), compared to healthy controls (Figure 3). There were no significant associations between neurometabolites, neuronal integrity markers and peripheral cytokines. In the SZ group positive associations were found between absolute glutamatergic and inflammatory neurometabolites in the anterior cingulate cortex (NAA and Glu (P<0.0001), NAA+NAAG and Glu (P<0.001), mI and Glu (p<0.0001), mI and Glx (p<0.01)) (Figure 4). The positive associations found between mI in the left thalamus and mI/Cr+PCr in bilateral ACC (p<0.01) in the MAP group, were significantly greater than these associations in healthy controls (Figure 4).
***Figure 3***