Graphical abstract
Recent research report glutamatergic dysfunction and involvement of
inflammatory pathways in schizophrenia and methamphetamine-induced
psychosis. Comparison between neurometabolites in thalamo-cortical
circuitry across schizophrenia and methamphetamine-induced psychosis is
limited, and no studies have assessed the relationship between
neurometabolites and peripheral cytokines in living humans.
Glutamatergic and neuroinflammatory neurometabolites and neuronal
integrity markers in thalamo-cortical circuitry were measured and
relationships were determined with peripheral cytokine levels in both
disorders. Important differences in the neurobiology of schizophrenia
and methamphetamine-induced psychosis were highlighted.