Graphical abstract
Recent research report glutamatergic dysfunction and involvement of inflammatory pathways in schizophrenia and methamphetamine-induced psychosis. Comparison between neurometabolites in thalamo-cortical circuitry across schizophrenia and methamphetamine-induced psychosis is limited, and no studies have assessed the relationship between neurometabolites and peripheral cytokines in living humans. Glutamatergic and neuroinflammatory neurometabolites and neuronal integrity markers in thalamo-cortical circuitry were measured and relationships were determined with peripheral cytokine levels in both disorders. Important differences in the neurobiology of schizophrenia and methamphetamine-induced psychosis were highlighted.