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Fig. 1. Chemical structures of RA (A), A1 (B) and PPD (C).
Fig. 2. Precursor ion and product ion spectra of RA (a), A1 (b)
and PPD (c).
Fig. 3. Characterization of the analyte fragments. (a) m/z 359
→ 161 for RA; (b) m/z 358 → 161 for A1; and (c) m/z 164 → 146 for PPD.
Fig. 4. Representative SRM chromatograms of PPD (IS, I), RA
(II) and A1 (III) in rat plasma: (a) a blank rat plasma sample; (b) a
blank rat plasma sample spiked with PPD (100 ng/ml), RA (10 ng/ml), and
A1 (10 ng/ml); (C) a rat plasma sample 30 min after an oral dose of RA
and A1 was administered at 10 mg/kg (calculated as RA) to a
Sprague–Dawley rat.
Fig. 5. Mean plasma concentration–time profiles of RA and A1
administered to 12 Sprague–Dawley rats (mean ± SD).