3.1 Effect of COVID-19 lockdown on DSI in MHD patients
A total of 130 patients had their first assessment before the lockdown. During the lockdown period, only 106 of the 130 cases participated in the second evaluation. Finally, 106 patients who were assessed twice were included in the trial. 60.4% of the patients were male (n = 64). The mean age of patients was 56.0 (SD = 13.1) years. We observed that DSI severity in MHD patients during lockdown was higher than that before lockdown (Table 1). In particular, itching, trouble staying asleep, bone or joint pain, muscle cramps, feeling irritable, difficulty concentrating, headache, constipation, and feeling nervous were observed (P <0.05, Table 1). Moreover, the prevalence of fatigue (PSQI>5) and poor sleep (FACIT-F≤34) was higher during lockdown than before lockdown (P <0.05).