Key Messages
  1. Chemotherapy ototoxicity is a well known adverse effect that has few treatment options and that has not been sufficiently studied in the adult population.
  2. Tinnitus and vertigo are distressing symptoms overlooked in cisplatin-induced ototoxicity research.
  3. Pharmacological interventions to prevent cisplatin induced hearing loss are controversial given their mild efficacy and potential side effects. Future investigations of sodium thiosulfate for preventing cisplatin-induced ototoxicity are warranted.