Author Type of study Type of Cancer Cisplatin dose Ototoxicity assessment Intervention Follow-up time Outcome Adverse Reactions
Weijl et al. 2004 RCT 50
Any cancer
100mg/m2
Audiometry
1000mg Vitamin C, 400mg Vitamin E, 100mg selenium
12 months
Patients with the highest micronutrient antioxidant score had less loss of high-tone hearing (conduction threshold at 8.0 Hz 2.8 vs. 14.4 dB; p=0.028).
Not reported
Villani et al. 2016 RCT 108
Solid malignancies
Not reported
Audiometry and evoked brainstem responses
400mg Vitamin E per day
3 months
A significant hearing loss in the control group at both 2000 Hz and 8000 Hz. Conversely, audiograms did not show significant changes in the active group at 2000, 4000, and 8000 Hz.
Not reported
Scasso et al. 2017 Case-control study 26
Any cancer
100 mg/m2
Audiometry
Coenzyme Q10 + Multivitamins
4 months
A higher hearing impairment in the control patients occurred in 6 out of 8 patients (75.0%). Otherwise, only 2 out of 18 patients (11.1%) who took the supplement daily were affected (P < 0.01).
Not reported
Campbell et al. 2022 RCT 27 Head and neck Genitourinary Esophagus
50 mg/m2
Audiometry
D-methionine (100 mg/kg) fractionated into two doses
5 cycles of cisplatin
Placebo group showed a threshold shifts from baseline to post-treatment at 10 Hz (-13.65 dB p =0.008), 11.2 Hz (-16.15dB p=0.008) and 12.5 Hz (-11.46dB p=0.03). The intervention group showed no significant threshold shifts.
No difference between groups