Here, we report the use of a methylene blue oral rinse for the treatment
of oral mucositis--associated pain. A child receiving chemotherapy for
acute lymphoblastic leukemia had progressive decline in clinical
condition from uncontrolled oral pain associated with mucositis.
Conventional therapy was shown to be ineffective and eventually
discontinued. The patient received a methylene oral rinse treatment,
which provided good pain control and allowed him to recover successfully
completing his chemotherapy. The use of the methylene blue oral rinse
can be a safe, inexpensive, and effective treatment for
mucositis-related oral pain in the pediatric cancer patient population.