Expression of dopamine receptors D1 and D2 in the dorsal striatum
Two main subtypes of dopamine receptors expressed in the dorsal striatum are D1R and D2R (Meador-Woodruff, 1996). Immunohistochemical analysis revealed an increase in the expression of D1R in the dorsal striatum of HU mice in comparison with both GH and SI groups, while normally loaded GH and SI animals demonstrated similar expression (Figure 3A, C). At the same time D2R expression in all investigated groups showed no significant difference (Figure 3B, D).