Figure 3. Univariate MR analysis between the various allergic
diseases and severe COVID-19.
P: P-value of the causal estimate; Cases: The number of cases in the
database of exposure; Controls: The number of controls in the database
of exposure; IVs: the number of SNPs used as instrumental variables; OR:
odds ratio; CI: confidence interval.
Figure 4. Scatterplots of potential effects of SNPs on allergic
disease, atopic dermatitis, mixedasthma, and childhood asthma
versus severe COVID-19.
(A) allergic disease (asthma, hay fever, or eczema); (B) atopic
dermatitis; (C) mixed asthma; (D) childhood asthma. Analyses were
conducted using inverse variance-weighted (IVW) mode, MR-Egger,
weighted-median, and weighted mode.
The slope of each line represents
the estimated MR effect for each approach.