Funding statement
This work was funded by the National Natural Science Foundation of China (No.81830097) (https://www.nsfc.gov.cn/) to QL; also CAMS Innovation Fund for Medical Sciences (CIFMS) No.2021-I2M-1-059, the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2020-RC320-003) and Special Program of National Natural Science Foundation of China (NO. 32141004) to QL.