1. Background
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system (CNS) inflammatory disease. It was first described by Pittock et al in 2010(Pittock, et al.,2010). CLIPPERS are rarely reported in China, Yang B et al(Yang, et al.,2021) first summarized the clinical manifestations of CLIPPERS in China. All of the patients developed a neurological syndrome dominated by gait ataxia and dysarthria, none of them with intracranial hemorrhage(Yang, et al.,2021). Our literature search revealed only three reported cases of intraparenchymal hemorrhage secondary to CLIPPERS(Buttmann, et al.,2013; Blaabjerg, et al.,2016; Sudhakar, et al.,2021). Buttmann et al have reported a case of subacute bleeding in the right cerebellar(Buttmann, et al.,2013). For reasons unknown, there have been fewer reported cases of cerebral hemorrhage secondary to CLIPPERS. Our case is unique in that we present a case of a 54-year-old man who developed a cerebellar hemorrhage following CLIPPERS. To our knowledge, this is the first case reporting cerebellar hemorrhage secondary to CLIPPERS in China and the second report of pathologic lesions showing ring-enhancing hypermetabolism on PET/CT(Sudhakar, et al.,2021).