1. Background
Chronic lymphocytic inflammation with pontine perivascular enhancement
responsive to steroids (CLIPPERS) is a rare central nervous system (CNS)
inflammatory disease. It was first described by Pittock et al in
2010(Pittock, et al.,2010). CLIPPERS are rarely reported in China, Yang
B et al(Yang, et al.,2021) first summarized the clinical manifestations
of CLIPPERS in China. All of the
patients developed a neurological syndrome dominated by gait ataxia and
dysarthria, none of them with intracranial hemorrhage(Yang, et
al.,2021). Our literature search revealed only three reported cases of
intraparenchymal hemorrhage secondary to CLIPPERS(Buttmann, et al.,2013;
Blaabjerg, et al.,2016; Sudhakar, et al.,2021). Buttmann et al have
reported a case of subacute bleeding in the right cerebellar(Buttmann,
et al.,2013). For reasons unknown, there have been fewer reported cases
of cerebral hemorrhage secondary to CLIPPERS. Our case is unique in that
we present a case of a 54-year-old man who developed a cerebellar
hemorrhage following CLIPPERS. To our knowledge, this is the first case
reporting cerebellar hemorrhage secondary to CLIPPERS in China and the
second report of pathologic lesions showing ring-enhancing
hypermetabolism on PET/CT(Sudhakar, et al.,2021).