3 Result
Patients’ characteristics were presented in Table1 . Of the 965 study patients, the median age was 41 years (range 35-50). In the pathology result of diagnosis before the conization, 2.5% had LSIL, 97.5% had HSIL or cervical cancer. Only a small fraction (3.7%) of the pathological results of the conization tissue were negative for intraepithelial lesions or malignancy (NILM), HSIL and cervical cancer account for the majority (74.2%). The median values of cone depth and volume were 1.80cm (range 1.30-2.30) and 1.81cm3 (rang 1.18-2.94) respectively.
We evaluated the correlation between patient characteristics and cone margin status, we used Mann-Whitney U test and chi-square test to evaluate the association of factors and positive margins (Table 2 ). Older age (p=0.007), the pathology result of conization tissue was HSIL or cervical cancer (p\(<\)0.001), choose to make additional cuts (p\(<\)0.001), smaller cone depth (p\(<\)0.001) and smaller cone volume (p=0.01) had significantly higher rate of positive margin in total subjects.
Multivariable logistic regression analysis revealed that making additional cuts (odds ratio [OR], 2.480; 95%CI 1.608 to 3.826; p=0.01), the pathology result of conization is HSIL or cervical cancer (OR,13.203; 95%CI,6.024 to 28.936; p\(<\)0.001), age (OR,1.036; 95%CI, 1.017 to 1.054; p\(<\)0.001) and smaller cone depth (OR, 0.591; 95%CI, 0.362 to 0.965, p=0.036) were independent risk factors of positive margin group (Fig. 2) .
Subsequently, we analyzed the additional cuts rate and the effective additional cuts rate of doctors, who had the habit of making additional cuts (Table 3) . In our study, a total of 64 doctors participated in the conization surgery, and six of them (9.4%) had the habit of making additional cuts, and four of the doctors had an additional cuts rate greater than 80%. Of these six doctors, expect for one doctor’s additional cut was ineffective, the rest of the doctors had a relatively high effective additional cut rate.
Next, Table 4 shows that the cone volume in the additional cuts group was from 0.89cm3 to 1.57cm3 (median = 1.25cm3), there was an extremely significant difference (p\(<\)0.001) in cone volume between the not making additional cuts group and the making additional cuts group. On whether the doctor had the habit of making the additional cuts group, doctors who had the habit of making additional cuts had significantly smaller cone volume than doctors who not had this habit (median=1.16 cm3 and 2.20 cm3, respectively; p\(<\)0.001).