Study Selection and Study Characteristics
From the three electronic databases, 2985 studies were identified, and after the removal of duplicates, screening based on title and abstract, and full-texts, 16 studies were eligible for inclusion. Additionally, 18 relevant studies were identified through hand-searching from organization websites and citation searching, of which 15 were included in this systematic review. A total of 31 studies with 9189 Mpox patients were included in this systematic review and subsequent meta-analysis (Figure 1, Table S3 ). Of the included studies, two studies were multinational [4, 5], nine studies were from Spain [6-14], followed by seven studies from the United States of America [15-21], four from Congo [22-25], three from France [26-28] and Nigeria [29-31], and one each from Israel [32], Sudan [33], and the United Kingdom [34] (Table 1 ). The studies were comprised of 18 case series [5, 6, 9, 11, 12, 14, 15, 17-19, 21, 23, 25, 28, 29, 31, 32, 34], eight cross-sectional [4, 7, 8, 16, 20, 22, 30, 33], and five cohort studies [10, 13, 24, 26, 27]. Additionally, studies were done on adult patients, pediatrics, and a mix of the two. The most common method of detection for MPV was through PCR, while other methods of detection include Antibody Test/Serology, Electron Microscopy, ELISA, Genomic Sequencing, Immunohistochemistry, and Viral Culture, among others.