Effective tissue sealing of resected gastrointestinal organs (GO) is essential to improvingtreatment and healing of wounds. Successful healing of GO often requires gentle tissue handling,hemodynamic stability with tissue oxygenation, and adequate surgical repair. The most commontechniques utilized for wound closure in GO are hand-sewn sutures. However, these methodsrequire high precision and often are associated with anastomotic leakages. In this work, I reviewcurrent clinical advancements in techniques and technologies used to improve wound healing for GO.