Introduction
Epstein-Barr virus was first discovered 50 years ago through its
association with Burkitt’s lymphoma, and as seen, the virus encodes a
set of products that have been found to have an interaction or
similarity between them and a wide range of Anti-apoptotic molecules,
cytokines may promote immortalization in cells and
transformation.1-3 The delayed infection hypothesis
proposed by Greaves also suggests that late exposure to infectious
agents, as opposed to early exposure, can lead to an abnormal immune
response that by an indirect mechanism can increase leukogenesis and
acute lymphocytic leukemia.4
Lymphoma is divided into two categories: Hodgkin’s and non-Hodgkin’s.
The most common site of NHL lymph node proliferation is the
gastrointestinal tract, which accounts for 15 to 20 percent of all
cases.5
Obstructive jaundice is one of the manifestations of malignancies that
is usually caused by external compression of the common bile duct, but
many cases of malignant infiltration of the internal bile duct have not
been reported. Acute lymphoblastic leukemia (ALL), which is a clonal
hematologic disorder and is known as non-Hodgkin’s lymphoma, also has
symptoms such as fever and fatigue and thrombocytopenia and
hepatomegaly. However, there are limited reports of liver failure and
jaundice as early manifestations of the disease.6-10
Here we look at a case that
presents with symptoms of jaundice and lymphadenopathy and is known in
tests for Epstein-Barr virus to cause acute lymphoblastic leukemia in
this patient.