Resting-state fMRI reveals a whole brain ALFF signature for chronic corneal pain.
The rs-fMRI technology was performed to examine changes in brain structure and neuronal activity in chronic corneal pain mice. Mice were scanned under resting state conditions 28 days after surgery. The final t-map of ALFF (Fig. 2) revealed significantly decreased ALFF in primary motor area (Mop), secondary motor area (Mos), primary somatosensory area (SSp)-upper limb, SSp-mouth, right SSp-nose, and right olfactory areas (OLF), right hippocampal region (HIP), right retrohippocampal region (RHP), right cortical subplate (CTX)-subplate, right anterior cingulate area (ACA)-dorsal, right prelimbic area (PL), increased ALFF in the supplemental somatosensory area (S2), gustatory system (GU), visceral area (VISC), secondary auditory cortex, dorsal (AUD), secondary auditory cortex (AuV), agranular insular cortex, dorsal (AlD), agranular insular cortex, posterior (AlP), temporal association areas (TeA), perirhinal area (PERI), Ectorhinal cortex (Ect), OLF, HIP, RHP, CTX-sp, left striatum. The details of the brain regions, voxel, and peak T value in the DE and Sham groups are shown in Table 1.