Correlation analysis showed ALFF values in insular cortex
is related to corneal chemical sensitivity
To further examine the contribution of ALFF changed brain areas to
chronic corneal pain, we conducted a correlation analysis between ALFF
values of S2, AID, AIP, AuV, TeA, Ect, and eye blinking times after
chemical application.
We
found there was a significant correlation between the ALFF values of AID
and AIP, which belong to
the
insular cortex, and eye blinking times after
capsaicin (Figure 5b, P< 0.001; Figure5c,
p=0.014) and menthol application (Figure 5h, P< 0.001; Figure
5i, P< 0.001) according to the Pearson correlation analysis.
No correlation was observed in other brain regions at the P<
0.05 level. Therefore, we speculated
insular
cortex might play an essential role in chronic corneal pain.