Resting-state fMRI reveals a whole brain ALFF
signature for chronic corneal pain.
The rs-fMRI technology was performed to examine changes in brain
structure and neuronal activity in chronic corneal pain mice. Mice were
scanned under resting state conditions 28 days after surgery. The final
t-map of ALFF (Fig. 2) revealed significantly decreased ALFF in primary
motor area (Mop), secondary motor area (Mos), primary somatosensory area
(SSp)-upper limb, SSp-mouth, right SSp-nose, and right olfactory areas
(OLF), right hippocampal region (HIP), right retrohippocampal region
(RHP), right cortical subplate (CTX)-subplate, right anterior cingulate
area (ACA)-dorsal, right prelimbic area (PL), increased ALFF in the
supplemental somatosensory area (S2), gustatory system (GU), visceral
area (VISC), secondary auditory cortex, dorsal (AUD), secondary auditory
cortex (AuV), agranular insular cortex, dorsal (AlD), agranular insular
cortex, posterior (AlP), temporal association areas (TeA), perirhinal
area (PERI), Ectorhinal cortex (Ect), OLF, HIP, RHP, CTX-sp, left
striatum. The details of the brain regions, voxel, and peak T value in
the DE and Sham groups are shown in Table 1.