Integrin αM promotes macrophage alternative M2 polarization in hyperuricemia-related chronic kidney disease
Jing Liu a, Fan Guo a, Xiaoting Chenb, Ping Fu a, *, Liang Maa, *
a Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China.
b Animal Experimental Center, West China Hospital of Sichuan University, Chengdu 610041, China
*Correspondence : Liang Ma and Ping Fu, Kidney Research Institute/Division of Nephrology, West China Hospital of Sichuan University, Guoxue alley 37#, Wuhou District, Chengdu 610041, China. Email: fupinghx@scu.edu.cn (P Fu), liang_m@scu.edu.cn (L Ma).
Running Title: Macrophage ITGAM in hyperuricemia-related CKD
Word counts: 3539 words (excluding references and figure legends)
Data availability: Most of data relative to this work are contained within this manuscript. The data that support the findings of this study are available from the corresponding author upon reasonable request.
Acknowledgments: This study was supported by the Science/Technology Project of Sichuan province [2021YFQ0027 and 2022YFS0589].
Conflict of interest statement : None
Author contribution statement: J.L., L.M., and P.F. conceived and designed the experiments. J.L, F.G, X-T.C., and L.M. performed experiments. J.L. and L.M. performed the statistical analyses. J.L., F.G., and L.M. wrote the initial draft of the manuscript. L.M.revised the manuscript. All authors have critically reviewed and revised this paper and approved its final version to be submitted.
Ethics approval statement: This study received approval granted by Animal Care and Use Ethics Committee of Sichuan University (Approval No. 20220303052).