References:
Altieri, D. C., Agbanyo, F. R., Plescia, J., Ginsberg, M. H., Edgington,
T. S., & Plow, E. F. (1990, Jul 25). A unique recognition site mediates
the interaction of fibrinogen with the leukocyte integrin Mac-1
(CD11b/CD18). J Biol Chem, 265 (21), 12119-12122.https://www.ncbi.nlm.nih.gov/pubmed/1973686
Bakris, G. L., Doghramji, P. P., Keenan, R. T., & Silber, S. H. (2014,
Jan). CaseBook challenges: Managing gout, hyperuricemia and
comorbidities – dialogue with the experts. Am J Med, 127 (1),
S1.https://doi.org/10.1016/j.amjmed.2013.11.001
Berton, G., & Lowell, C. A. (1999, Sep). Integrin signalling in
neutrophils and macrophages. Cell Signal, 11 (9), 621-635.https://doi.org/10.1016/s0898-6568(99)00003-0
Bolos, V., Gasent, J. M., Lopez-Tarruella, S., & Grande, E. (2010, Jun
24). The dual kinase complex FAK-Src as a promising therapeutic target
in cancer. Onco Targets Ther, 3 , 83-97.https://doi.org/10.2147/ott.s6909
Chavakis, T., Bierhaus, A., Al-Fakhri, N., Schneider, D., Witte, S.,
Linn, T., Nagashima, M., Morser, J., Arnold, B., Preissner, K. T., &
Nawroth, P. P. (2003, Nov 17). The pattern recognition receptor (RAGE)
is a counterreceptor for leukocyte integrins: a novel pathway for
inflammatory cell recruitment. J Exp Med, 198 (10), 1507-1515.https://doi.org/10.1084/jem.20030800
Chen-Xu, M., Yokose, C., Rai, S. K., Pillinger, M. H., & Choi, H. K.
(2019, Jun). Contemporary Prevalence of Gout and Hyperuricemia in the
United States and Decadal Trends: The National Health and Nutrition
Examination Survey, 2007-2016. Arthritis Rheumatol, 71 (6),
991-999.https://doi.org/10.1002/art.40807
Dehnadi, A., Benedict Cosimi, A., Neal Smith, R., Li, X., Alonso, J. L.,
Means, T. K., & Arnaout, M. A. (2017, Jan 10). Prophylactic orthosteric
inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic
kidney failure in cynomolgus monkeys. Nat Commun, 8 , 13899.https://doi.org/10.1038/ncomms13899
Dunne, J. L., Ballantyne, C. M., Beaudet, A. L., & Ley, K. (2002, Jan
1). Control of leukocyte rolling velocity in TNF-alpha-induced
inflammation by LFA-1 and Mac-1. Blood, 99 (1), 336-341.https://doi.org/10.1182/blood.v99.1.336
Ehlers, R., Ustinov, V., Chen, Z., Zhang, X., Rao, R., Luscinskas, F.
W., Lopez, J., Plow, E., & Simon, D. I. (2003, Oct 6). Targeting
platelet-leukocyte interactions: identification of the integrin Mac-1
binding site for the platelet counter receptor glycoprotein Ibalpha.J Exp Med, 198 (7), 1077-1088.https://doi.org/10.1084/jem.20022181
Fan, Z., & Ley, K. (2015). Leukocyte arrest: Biomechanics and molecular
mechanisms of beta2 integrin activation. Biorheology, 52 (5-6),
353-377.https://doi.org/10.3233/BIR-15085
Feng, Y., Ren, J., Gui, Y., Wei, W., Shu, B., Lu, Q., Xue, X., Sun, X.,
He, W., Yang, J., & Dai, C. (2018, Jan). Wnt/beta-Catenin-Promoted
Macrophage Alternative Activation Contributes to Kidney Fibrosis.J Am Soc Nephrol, 29 (1), 182-193.https://doi.org/10.1681/ASN.2017040391
Gimenez, A., Duch, P., Puig, M., Gabasa, M., Xaubet, A., & Alcaraz, J.
(2017, Nov 16). Dysregulated Collagen Homeostasis by Matrix Stiffening
and TGF-beta1 in Fibroblasts from Idiopathic Pulmonary Fibrosis
Patients: Role of FAK/Akt. Int J Mol Sci, 18 (11).https://doi.org/10.3390/ijms18112431
Guan, J. L. (1997, Oct). Focal adhesion kinase in integrin signaling.Matrix Biol, 16 (4), 195-200.https://doi.org/10.1016/s0945-053x(97)90008-1
Guan, J. L. (2010, Apr). Integrin signaling through FAK in the
regulation of mammary stem cells and breast cancer. IUBMB Life,
62 (4), 268-276.https://doi.org/10.1002/iub.303
Hu, X., Han, C., Jin, J., Qin, K., Zhang, H., Li, T., Li, N., & Cao, X.
(2016, May 18). Integrin CD11b attenuates colitis by strengthening
Src-Akt pathway to polarize anti-inflammatory IL-10 expression.Sci Rep, 6 , 26252.https://doi.org/10.1038/srep26252
Jang, T. H., Huang, W. C., Tung, S. L., Lin, S. C., Chen, P. M., Cho, C.
Y., Yang, Y. Y., Yen, T. C., Lo, G. H., Chuang, S. E., & Wang, L. H.
(2022, Jun 15). MicroRNA-485-5p targets keratin 17 to regulate oral
cancer stemness and chemoresistance via the
integrin/FAK/Src/ERK/beta-catenin pathway. J Biomed Sci, 29 (1),
42.https://doi.org/10.1186/s12929-022-00824-z
Johnson, R. J., Bakris, G. L., Borghi, C., Chonchol, M. B., Feldman, D.,
Lanaspa, M. A., Merriman, T. R., Moe, O. W., Mount, D. B., Sanchez
Lozada, L. G., Stahl, E., Weiner, D. E., & Chertow, G. M. (2018, Jun).
Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and
Cardiovascular Disease: Report of a Scientific Workshop Organized by the
National Kidney Foundation. Am J Kidney Dis, 71 (6), 851-865.https://doi.org/10.1053/j.ajkd.2017.12.009
Kanse, S. M., Matz, R. L., Preissner, K. T., & Peter, K. (2004, Dec).
Promotion of leukocyte adhesion by a novel interaction between
vitronectin and the beta2 integrin Mac-1 (alphaMbeta2, CD11b/CD18).Arterioscler Thromb Vasc Biol, 24 (12), 2251-2256.https://doi.org/10.1161/01.ATV.0000146529.68729.8b
Kornberg, L. J., Earp, H. S., Turner, C. E., Prockop, C., & Juliano, R.
L. (1991, Oct 1). Signal transduction by integrins: increased protein
tyrosine phosphorylation caused by clustering of beta 1 integrins.Proc Natl Acad Sci U S A, 88 (19), 8392-8396.https://doi.org/10.1073/pnas.88.19.8392
Lange-Sperandio, B., Schimpgen, K., Rodenbeck, B., Chavakis, T.,
Bierhaus, A., Nawroth, P., Thornhill, B., Schaefer, F., & Chevalier, R.
L. (2006, Jan). Distinct roles of Mac-1 and its counter-receptors in
neonatal obstructive nephropathy. Kidney Int, 69 (1), 81-88.https://doi.org/10.1038/sj.ki.5000017
Lee, H., Fessler, M. B., Qu, P., Heymann, J., & Kopp, J. B. (2020, Jul
13). Macrophage polarization in innate immune responses contributing to
pathogenesis of chronic kidney disease. BMC Nephrol, 21 (1), 270.https://doi.org/10.1186/s12882-020-01921-7
Liu, J., Huang, R., Li, X., Guo, F., Li, L., Zeng, X., Ma, L., & Fu, P.
(2021, Mar 1). Genetic inhibition of FABP4 attenuated endoplasmic
reticulum stress and mitochondrial dysfunction in rhabdomyolysis-induced
acute kidney injury. Life Sci, 268 , 119023.https://doi.org/10.1016/j.lfs.2021.119023
Lu, J., Hou, X., Yuan, X., Cui, L., Liu, Z., Li, X., Ma, L., Cheng, X.,
Xin, Y., Wang, C., Zhang, K., Wang, X., Ren, W., Sun, R., Jia, Z., Tian,
Z., Mi, Q. S., & Li, C. (2018, Jan). Knockout of the urate oxidase gene
provides a stable mouse model of hyperuricemia associated with metabolic
disorders. Kidney Int, 93 (1), 69-80.https://doi.org/10.1016/j.kint.2017.04.031
Lv, J., Bai, R., Wang, L., Gao, J., & Zhang, H. (2018, Oct 16).
Artesunate may inhibit liver fibrosis via the FAK/Akt/beta-catenin
pathway in LX-2 cells. BMC Pharmacol Toxicol, 19 (1), 64.https://doi.org/10.1186/s40360-018-0255-9
MacDonald, B. T., Tamai, K., & He, X. (2009, Jul). Wnt/beta-catenin
signaling: components, mechanisms, and diseases. Dev Cell, 17 (1),
9-26.https://doi.org/10.1016/j.devcel.2009.06.016
Marek, I., Volkert, G., Hilgers, K. F., Bieritz, B., Rascher, W.,
Reinhardt, D. P., & Hartner, A. (2014). Fibrillin-1 and alpha8 integrin
are co-expressed in the glomerulus and interact to convey adhesion of
mesangial cells. Cell Adh Migr, 8 (4), 389-395.https://doi.org/10.4161/cam.28988
Martinez, L., Li, X., Ramos-Echazabal, G., Faridi, H., Zigmond, Z. M.,
Santos Falcon, N., Hernandez, D. R., Shehadeh, S. A., Velazquez, O. C.,
Gupta, V., & Vazquez-Padron, R. I. (2020, Nov 1). A Genetic Model of
Constitutively Active Integrin CD11b/CD18. J Immunol, 205 (9),
2545-2553.https://doi.org/10.4049/jimmunol.1901402
Milanesi, S., Verzola, D., Cappadona, F., Bonino, B., Murugavel, A.,
Pontremoli, R., Garibotto, G., & Viazzi, F. (2019, Jul). Uric acid and
angiotensin II additively promote inflammation and oxidative stress in
human proximal tubule cells by activation of toll-like receptor 4.J Cell Physiol, 234 (7), 10868-10876.https://doi.org/10.1002/jcp.27929
Muller, U., Wang, D., Denda, S., Meneses, J. J., Pedersen, R. A., &
Reichardt, L. F. (1997, Mar 7). Integrin alpha8beta1 is critically
important for epithelial-mesenchymal interactions during kidney
morphogenesis. Cell, 88 (5), 603-613.https://doi.org/10.1016/s0092-8674(00)81903-0
Murray, P. J. (2017, Feb 10). Macrophage Polarization. Annu Rev
Physiol, 79 , 541-566.https://doi.org/10.1146/annurev-physiol-022516-034339
Niehrs, C. (2012, Dec). The complex world of WNT receptor signalling.Nat Rev Mol Cell Biol, 13 (12), 767-779.https://doi.org/10.1038/nrm3470
Oluwo, O., & Scialla, J. J. (2021, Mar 8). Uric Acid and CKD
Progression Matures with Lessons for CKD Risk Factor Discovery.Clin J Am Soc Nephrol, 16 (3), 476-478.https://doi.org/10.2215/CJN.10650620
Pan, J., Shi, M., Li, L., Liu, J., Guo, F., Feng, Y., Ma, L., & Fu, P.
(2019, Jan). Pterostilbene, a bioactive component of blueberries,
alleviates renal fibrosis in a severe mouse model of hyperuricemic
nephropathy. Biomed Pharmacother, 109 , 1802-1808.https://doi.org/10.1016/j.biopha.2018.11.022
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T.,
Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U.,
Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A.,
Lazic, S. E., Lidster, K., MacCallum, C. J., Macleod, M., Pearl, E. J.,
Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S.,
Silberberg, S. D., Steckler, T., & Wurbel, H. (2020, Jul). The ARRIVE
guidelines 2.0: Updated guidelines for reporting animal research.PLoS Biol, 18 (7), e3000410.https://doi.org/10.1371/journal.pbio.3000410
Podolnikova, N. P., Podolnikov, A. V., Haas, T. A., Lishko, V. K., &
Ugarova, T. P. (2015, Feb 17). Ligand recognition specificity of
leukocyte integrin alphaMbeta2 (Mac-1, CD11b/CD18) and its functional
consequences. Biochemistry, 54 (6), 1408-1420.https://doi.org/10.1021/bi5013782
Pozzi, A., & Zent, R. (2013, Jun). Integrins in kidney disease. J
Am Soc Nephrol, 24 (7), 1034-1039.https://doi.org/10.1681/ASN.2013010012
Ren, Q., Wang, B., Guo, F., Huang, R., Tan, Z., Ma, L., & Fu, P.
(2021). Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic
Nephropathy via Suppressing TGFbeta/SMAD3 and JAK2/STAT3 Signaling
Pathways. Front Pharmacol, 12 , 792139.https://doi.org/10.3389/fphar.2021.792139
Rosetti, F., & Mayadas, T. N. (2016, Jan). The many faces of Mac-1 in
autoimmune disease. Immunol Rev, 269 (1), 175-193.https://doi.org/10.1111/imr.12373
Ross, G. D., & Lambris, J. D. (1982, Jan 1). Identification of a
C3bi-specific membrane complement receptor that is expressed on
lymphocytes, monocytes, neutrophils, and erythrocytes. J Exp Med,
155 (1), 96-110.https://doi.org/10.1084/jem.155.1.96
Sato, Y., Feig, D. I., Stack, A. G., Kang, D. H., Lanaspa, M. A., Ejaz,
A. A., Sanchez-Lozada, L. G., Kuwabara, M., Borghi, C., & Johnson, R.
J. (2019, Jul 11). The case for uric acid-lowering treatment in patients
with hyperuricaemia and CKD. Nat Rev Nephrol .https://doi.org/10.1038/s41581-019-0174-z
Sethi, S., D’Agati, V. D., Nast, C. C., Fogo, A. B., De Vriese, A. S.,
Markowitz, G. S., Glassock, R. J., Fervenza, F. C., Seshan, S. V., Rule,
A., Racusen, L. C., Radhakrishnan, J., Winearls, C. G., Appel, G. B.,
Bajema, I. M., Chang, A., Colvin, R. B., Cook, H. T., Hariharan, S.,
Herrera Hernandez, L. P., Kambham, N., Mengel, M., Nath, K. A., Rennke,
H. G., Ronco, P., Rovin, B. H., & Haas, M. (2017, Apr). A proposal for
standardized grading of chronic changes in native kidney biopsy
specimens. Kidney Int, 91 (4), 787-789.https://doi.org/10.1016/j.kint.2017.01.002
Takada, Y., Ye, X., & Simon, S. (2007). The integrins. Genome
Biol, 8 (5), 215.https://doi.org/10.1186/gb-2007-8-5-215
Villanueva, V., Li, X., Jimenez, V., Faridi, H. M., & Gupta, V. (2022,
Jul). CD11b agonists offer a novel approach for treating lupus
nephritis. Transl Res, 245 , 41-54.https://doi.org/10.1016/j.trsl.2022.03.001
Wen, L., Yang, H., Ma, L., & Fu, P. (2021, Jan 3). The roles of NLRP3
inflammasome-mediated signaling pathways in hyperuricemic nephropathy.Mol Cell Biochem .https://doi.org/10.1007/s11010-020-03997-z
Wolf, D., Anto-Michel, N., Blankenbach, H., Wiedemann, A., Buscher, K.,
Hohmann, J. D., Lim, B., Bauml, M., Marki, A., Mauler, M., Duerschmied,
D., Fan, Z., Winkels, H., Sidler, D., Diehl, P., Zajonc, D. M.,
Hilgendorf, I., Stachon, P., Marchini, T., Willecke, F., Schell, M.,
Sommer, B., von Zur Muhlen, C., Reinohl, J., Gerhardt, T., Plow, E. F.,
Yakubenko, V., Libby, P., Bode, C., Ley, K., Peter, K., & Zirlik, A.
(2018, Feb 6). A ligand-specific blockade of the integrin Mac-1
selectively targets pathologic inflammation while maintaining protective
host-defense. Nat Commun, 9 (1), 525.https://doi.org/10.1038/s41467-018-02896-8
Yamaura, T., Kasaoka, T., Iijima, N., Kimura, M., & Hatakeyama, S.
(2019, Apr 2). Evaluation of therapeutic effects of FAK inhibition in
murine models of atherosclerosis. BMC Res Notes, 12 (1), 200.https://doi.org/10.1186/s13104-019-4220-5
Yang, Y., Ye, Y. C., Chen, Y., Zhao, J. L., Gao, C. C., Han, H., Liu, W.
C., & Qin, H. Y. (2018, Jul 18). Crosstalk between hepatic tumor cells
and macrophages via Wnt/beta-catenin signaling promotes M2-like
macrophage polarization and reinforces tumor malignant behaviors.Cell Death Dis, 9 (8), 793.https://doi.org/10.1038/s41419-018-0818-0
Zhao, H., Lu, J., He, F., Wang, M., Yan, Y., Chen, B., Xie, D., Xu, C.,
Wang, Q., Liu, W., Yu, W., Xi, Y., Yu, L., Yamamoto, T., Koyama, H.,
Wang, W., Zhang, C., & Cheng, J. (2022). Hyperuricemia contributes to
glucose intolerance of hepatic inflammatory macrophages and impairs the
insulin signaling pathway via IRS2-proteasome degradation. Front
Immunol, 13 , 931087.https://doi.org/10.3389/fimmu.2022.931087
Zirlik, A., Maier, C., Gerdes, N., MacFarlane, L., Soosairajah, J.,
Bavendiek, U., Ahrens, I., Ernst, S., Bassler, N., Missiou, A., Patko,
Z., Aikawa, M., Schonbeck, U., Bode, C., Libby, P., & Peter, K. (2007,
Mar 27). CD40 ligand mediates inflammation independently of CD40 by
interaction with Mac-1. Circulation, 115 (12), 1571-1580.https://doi.org/10.1161/CIRCULATIONAHA.106.683201