Acknowledgements
The authors acknowledge the financial support provided through the projects PTDC/BTM-ORG/31564/2017, financed by the Portuguese Foundation for Science and Technology (FCT) and cofinanced by European Regional Development Fund (FEDER) and Operational Programme for Competitiveness and Internationalization (POCI). M.R.C. acknowledges her post-doctoral contract TERM RES Hub – Scientific infrastructure for Tissue Engineering and Regenerative Medicine Ref Norte-01-0145-FEDER-02219015 and Portuguese Foundation for Science and Technology (FCT) for the financial support under the CEEC Individual 2021.00049.CEECIND. This work was partially supported by the IET A. F. Harvey Engineering Research Award 2018 (ENG ThE CANCER) and JusThera Project (NORTE-01-0145-FEDER-000055). D.C. acknowledges the Portuguese Foundation for Science and Technology (FCT) for the financial support under the CEEC Individual 2017 (CEECIND/00352/2017) program and the 2MATCH project (PTDC/BTM-ORG/28070/2017).