Subgroup analysis of efficacy
The influence of mean age, sex ratio, and duration of treatment was investigated (Supplementary Figure S17). As shown in Supplementary Table S4, the SUCRA score rankings were directly consistent across the subgroups.
Network meta-analysis ofiron metabolism indicators
Eight trials in DD CKD patients with a total of 16 arms reported the influence of these agents on hepcidin. Results revealed a significant reduction in Δhepcidin with Roxadustat (MD: -13.11µg/L, 95% CI: -24.65–1.57, p=0.03, I2=83%) and no statistical effects with Vadadustat and Molidustat compared with ESAs. The efficacy of HIF-PHIs on ΔTSAT, Δserum iron, ΔFerritin, and ΔTIBC was shown in Supplementary Figure S18.