Subgroup analysis of efficacy
The influence of mean age, sex ratio, and duration of treatment was
investigated (Supplementary Figure S17). As shown in Supplementary Table
S4, the SUCRA score rankings were directly consistent across the
subgroups.
Network meta-analysis ofiron metabolism
indicators
Eight trials in DD CKD patients with a total of 16 arms reported the
influence of these agents on hepcidin. Results revealed a significant
reduction in Δhepcidin with Roxadustat (MD: -13.11µg/L, 95% CI:
-24.65–1.57, p=0.03, I2=83%) and no statistical
effects with Vadadustat and Molidustat compared with ESAs. The efficacy
of HIF-PHIs on ΔTSAT, Δserum iron, ΔFerritin, and ΔTIBC was shown in
Supplementary Figure S18.