Hypotension and muscle spasms
The pooled results indicated no significant difference in hypotension (11 trials of 3 HIF-PHIs, containing 12763 participants[2, 12, 16, 27-31, 34, 35]) with Roxadustat, Daprodustat, and Vadadustat, compared to ESAs. Focus on muscle spasms, no increased risk was reported (9 trials of 4 HIF-PHIs, containing 4255 participants[12, 27-30, 33, 34, 40, 41]) between HIF-PHIs (Roxadustat, Daprodustat, Desidustat, and Molidustat) and ESAs (Figure 5).